CD74在抗原呈递、巨噬细胞移动抑制因子信号转导以及B细胞存活和内环境稳定中的重要作用。
The integral role of CD74 in antigen presentation, MIF signal transduction, and B cell survival and homeostasis.
作者信息
Bucala Richard, Shachar Idit
机构信息
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
出版信息
Mini Rev Med Chem. 2014;14(14):1132-8. doi: 10.2174/1389557515666150203144111.
Abstract
Molecules that link innate and adaptive immunity and regulate immune response in health and disease are now the focus of many studies. This review discusses CD74 and its ligand macrophage migration inhibitory factor (MIF), and their central position in linking these two components of the immune response by controlling survival of macrophages and B cells.
摘要
连接天然免疫和适应性免疫并在健康与疾病中调节免疫反应的分子，如今是众多研究的焦点。本综述讨论了CD74及其配体巨噬细胞移动抑制因子（MIF），以及它们通过控制巨噬细胞和B细胞的存活在连接免疫反应的这两个组成部分中所占据的核心地位。
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