Bonner Alice F, Field Terry S, Lemay Celeste A, Mazor Kathleen M, Andersen Daniel A, Compher Christina J, Tjia Jennifer, Gurwitz Jerry H
School of Nursing and Center for Health Policy, Northeastern University, Boston, Massachusetts.
J Am Geriatr Soc. 2015 Feb;63(2):302-8. doi: 10.1111/jgs.13230. Epub 2015 Jan 30.
To describe the rationales that providers and family members cite for the use of antipsychotic medications in people with dementia living in nursing homes (NHs).
Qualitative, descriptive study.
Twenty-six medium-sized and large facilities in five Centers for Medicare and Medicaid Services regions.
Individuals diagnosed with dementia who received an antipsychotic medication.
Data were collected from medical record abstraction and interviews with prescribers, administrators, direct care providers, and family members. Textual data from medical record abstraction and responses to open-ended interview questions were analyzed using directed content analysis techniques. A coding scheme was developed, and coded reasons for antipsychotic prescribing were summarized across all sources.
Major categories of reasons for use of antipsychotic medications in the 204 NH residents in the study sample were behavioral (n = 171), psychiatric (n = 159), emotional states (n = 105), and cognitive diagnoses or symptoms (n = 114). The most common behavioral reasons identified were verbal (n = 91) and physical (n = 85) aggression. For the psychiatric category, psychosis (n = 95) was most frequently described. Anger (n = 93) and sadness (n = 20) were the most common emotional states cited.
The rationale for use of antipsychotic drug therapy frequently relates to a wide variety of indications for which these drugs are not approved and for which evidence of efficacy is lacking. These findings have implications for clinical practice and policy.
描述疗养院(NHs)中痴呆患者使用抗精神病药物时,医护人员和家庭成员给出的理由。
定性描述性研究。
医疗保险和医疗补助服务中心五个地区的26家中型和大型机构。
被诊断患有痴呆且正在接受抗精神病药物治疗的个体。
从病历摘要以及对开处方者、管理人员、直接护理人员和家庭成员的访谈中收集数据。使用定向内容分析技术分析病历摘要中的文本数据以及对开放式访谈问题的回答。制定了编码方案,并汇总了所有来源中抗精神病药物处方的编码理由。
在研究样本的204名NH居民中,使用抗精神病药物的主要理由类别包括行为方面(n = 171)、精神方面(n = 159)、情绪状态(n = 105)以及认知诊断或症状(n = 114)。确定的最常见行为理由是言语攻击(n = 91)和身体攻击(n = 85)。在精神方面,最常描述的是精神病(n = 95)。提及最多的情绪状态是愤怒(n = 93)和悲伤(n = 20)。
使用抗精神病药物治疗的理由通常涉及这些药物未被批准的多种适应症,且缺乏疗效证据。这些发现对临床实践和政策具有启示意义。