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一项针对无合格诊断的长期疗养院居民使用抗精神病药物情况的观察性研究。

An observational study of antipsychotic medication use among long-stay nursing home residents without qualifying diagnoses.

作者信息

Phillips Lorraine J, Birtley Nancy M, Petroski Gregory F, Siem Carol, Rantz Marilyn

机构信息

University of Delaware School of Nursing, Newark, Delaware.

School of Nursing, University of Missouri, Columbia, Missouri.

出版信息

J Psychiatr Ment Health Nurs. 2018 Oct;25(8):463-474. doi: 10.1111/jpm.12488. Epub 2018 Aug 2.

Abstract

UNLABELLED

WHAT IS KNOWN ON THE SUBJECT?: In the United States, 15.5% of nursing home residents without qualifying diagnoses of schizophrenia, Huntington's' Disease, and/or Tourette Syndrome receive antipsychotic medications. Antipsychotic medications are used off-label (i.e., used in a manner the United States Food and Drug Administration's packaging insert does not specify) to treat neuropsychiatric symptoms, often before attempting nonpharmacologic interventions, despite evidence that this drug class is associated with significant adverse events including death. Less than optimal staffing resources and lack of access to geropsychiatric specialists are barriers to reducing antipsychotic use. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE?: Antipsychotic use occurred in 11.6% of nursing home residents without qualifying or potentially qualifying diagnoses (bipolar disorder and psychotic disorder); antipsychotic use was more prevalent in residents with a dementia diagnosis than those without. One additional registered nurse hour per resident day could reduce the odds of antipsychotic use by 52% and 56% for residents with and without a dementia diagnosis respectively. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Given the influence of total staffing and professional staff mix on risk of antipsychotic use, nursing home administrators may want to consider aspects of facility operation that impact antipsychotic use. More stringent Unites States' survey and certification standards for dementia care implemented in 2017 demand proactive person-centered care that promotes maximal well-being and functioning without risk of harm from inappropriate psychoactive medications. Mental health nurses have requisite training to provide expert person-centered care to nursing home residents with mental illness and geropsychiatric disorders.

ABSTRACT

Introduction Antipsychotic use in nursing homes varies widely across the United States; inadequate staffing, skill mix, and geropsychiatric training impede sustained improvement. Aim This study identified risk factors of antipsychotic use in long-stay residents lacking qualifying or potentially qualifying diagnoses. Method This secondary analysis used 2015 Minimum Data Set and cost report data from 458 Missouri nursing homes. The full sample (N = 29,679) was split into two subsamples: residents with (N = 15,114) and without (N = 14,565) a dementia diagnosis. Separate logistic regression models were run. Results Almost 15% of the dementia subsample and 8.4% of the nondementia subsample received an antipsychotic medication in the past week. Post-traumatic stress disorder, psychosis indicators, behavioral symptoms, anxiety medication with and without anxiety diagnosis, depression medication with and without depression diagnosis, and nurse staffing were among the strongest predictors of antipsychotic use in both subsamples. Simulation analyses showed decreased odds of receiving an antipsychotic in both subsamples when registered nurse hours matched the national average. Discussion Matching nurse staffing mix to the national average may improve antipsychotic use in nursing homes. Implications Knowledge of antipsychotic use risk factors use can inform care planning and staff education to minimize use of these medications in all but severe cases.

摘要

未标注

关于该主题已知的信息有哪些?在美国,15.5%没有精神分裂症、亨廷顿舞蹈症和/或妥瑞氏综合征确诊诊断的疗养院居民接受抗精神病药物治疗。抗精神病药物被用于非适应证用药(即,使用方式未得到美国食品药品监督管理局包装说明书的明确规定)来治疗神经精神症状,通常在尝试非药物干预之前就使用,尽管有证据表明这类药物会引发包括死亡在内的重大不良事件。人员配备资源不足以及难以获得老年精神科专家的帮助是减少抗精神病药物使用的障碍。本文对现有知识的补充是什么?在没有确诊或潜在确诊(双相情感障碍和精神障碍)的疗养院居民中,11.6%使用了抗精神病药物;与没有痴呆症诊断的居民相比,有痴呆症诊断的居民中抗精神病药物的使用更为普遍。每位居民每天增加一名注册护士工作时长,对于有和没有痴呆症诊断的居民而言,分别可将使用抗精神病药物的几率降低52%和56%。对实践有何启示?鉴于总人员配备和专业人员构成对抗精神病药物使用风险的影响,疗养院管理人员可能需要考虑设施运营中影响抗精神病药物使用的各个方面。2017年实施的针对痴呆症护理的更严格的美国调查和认证标准要求采取积极主动的以患者为中心的护理,以促进最大程度的福祉和功能,同时避免因不适当的精神活性药物造成伤害。心理健康护士经过必要的培训,能够为患有精神疾病和老年精神障碍的疗养院居民提供专业的以患者为中心的护理。

摘要

引言 美国各疗养院中抗精神病药物的使用情况差异很大;人员配备不足、技能组合不合理以及老年精神科培训不足阻碍了持续改善。目的 本研究确定了在长期居住且没有确诊或潜在确诊诊断的居民中使用抗精神病药物的风险因素。方法 本二次分析使用了来自密苏里州458家疗养院的2015年最低数据集和成本报告数据。完整样本(N = 29,679)被分为两个子样本:有痴呆症诊断的居民(N = 15,114)和没有痴呆症诊断的居民(N = 14,565)。分别运行了逻辑回归模型。结果 在过去一周内,近15%的痴呆症子样本和8.4%的非痴呆症子样本接受了抗精神病药物治疗。创伤后应激障碍、精神病指标、行为症状、有或没有焦虑诊断的抗焦虑药物、有或没有抑郁诊断的抗抑郁药物以及护士人员配备是两个子样本中抗精神病药物使用的最强预测因素。模拟分析表明,当注册护士工作时长达到全国平均水平时,两个子样本中接受抗精神病药物治疗的几率都会降低。讨论 将护士人员配备组合调整至全国平均水平可能会改善疗养院中抗精神病药物的使用情况。启示 了解抗精神病药物使用的风险因素有助于进行护理规划和员工教育,以尽量减少在非严重情况下这些药物的使用。

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