Tripp Geneva K, Good Kathryn L, Motta Monica J, Kass Philip H, Murphy Christopher J
Department of Surgical and Radiological Sciences, University of California Davis, Davis, CA, 95616, USA.
Department of Population Health and Reproduction, University of California Davis, Davis, CA, 95616, USA.
Vet Ophthalmol. 2016 Jan;19(1):38-42. doi: 10.1111/vop.12253. Epub 2015 Jan 27.
The purpose of this study was to determine impact of needle gauge, type, and orientation on average volume of drop dispensed.
Five needle gauges (22G, 23G, 25G, 27G, and 30G) were examined. For each gauge, volume of drop delivered was determined for standard sharp beveled tip, blunt tip, and after breaking off of the sharp needle from the hub. Vertical and horizontal orientation of the needle was tested for effect on drop volume for 22-G and 30-G sharp beveled needles.
Mean drop volume was affected by needle gauge, needle orientation, and whether the needle had been broken off from its hub. Mean drop volume scaled directly with needle diameter with drop volumes of 25.0 μL (±20.2) and 83.9 μL (±16.5) being found for 30-gauge and 22-gauge needles, respectively. Intermediate gauges (27, 25, 23G) yielded intermediate drop volumes. Blunt needles tended to produce larger drop volumes compared to sharp beveled needles, but these differences did not reach statistical significance. Breaking off of the needle from the hub produced substantially larger drop volumes with little difference being found between needle gauges. Average volumes of 1 drop from a 22-G vertical, 22-G horizontal, 30-G vertical, and 30-G horizontal sharp beveled needle were 20.2, 9.1, 10.1, and 3.3 μL, respectively.
These findings have relevance for controlled delivery of topical ophthalmic medications to patients.
本研究的目的是确定针的规格、类型和方向对滴出液平均体积的影响。
检查了五种针的规格(22G、23G、25G、27G和30G)。对于每种规格,测定了标准锐尖斜面、钝尖以及将锐针从针座上折断后的滴出液体积。测试了22G和30G锐尖斜面针的垂直和水平方向对滴出液体积的影响。
平均滴出液体积受针的规格、针的方向以及针是否已从针座上折断的影响。平均滴出液体积与针的直径直接相关,30G和22G针的滴出液体积分别为25.0 μL(±20.2)和83.9 μL(±16.5)。中间规格(27G、25G、23G)产生中间滴出液体积。钝针与锐尖斜面针相比往往产生更大的滴出液体积,但这些差异未达到统计学显著性。将针从针座上折断产生的滴出液体积显著更大,针的规格之间差异不大。22G垂直、22G水平、30G垂直和30G水平锐尖斜面针的1滴平均体积分别为20.2、9.1、10.1和3.3 μL。
这些发现与向患者控制性递送局部眼科药物相关。