Del Savio Lorenzo, Loi Michele, Stupka Elia
Bioethics. 2015 Oct;29(8):580-7. doi: 10.1111/bioe.12150. Epub 2015 Feb 3.
Recent evidence of intergenerational epigenetic programming of disease risk broadens the scope of public health preventive interventions to future generations, i.e. non existing people. Due to the transmission of epigenetic predispositions, lifestyles such as smoking or unhealthy diet might affect the health of populations across several generations. While public policy for the health of future generations can be justified through impersonal considerations, such as maximizing aggregate well-being, in this article we explore whether there are rights-based obligations supervening on intergenerational epigenetic programming despite the non-identity argument, which challenges this rationale in case of policies that affect the number and identity of future people. We propose that rights based obligations grounded in the interests of non-existing people might fall upon existing people when generations overlap. In particular, if environmental exposure in F0 (i.e. existing people) will affect the health of F2 (i.e. non-existing people) through epigenetic programming, then F1 (i.e. existing and overlapping with both F0 and F2) might face increased costs to address F2's condition in the future: this might generate obligations upon F0 from various distributive principles, such as the principle of equal opportunity for well being.
近期有关疾病风险的代际表观遗传编程的证据拓宽了公共卫生预防干预措施的范围,将其延伸至子孙后代,即尚未出生的人。由于表观遗传易感性的传递,吸烟或不健康饮食等生活方式可能会影响几代人群的健康。虽然可以通过非个人化的考量,如最大化总体福祉,来证明制定有利于子孙后代健康的公共政策的合理性,但在本文中,我们探讨了尽管存在非同一性论证(该论证在影响未来人口数量和身份的政策中对这一基本原理提出了挑战),基于权利的义务是否仍会在代际表观遗传编程中产生。我们提出,当世代重叠时,基于尚未出生之人利益的基于权利的义务可能会落在在世之人身上。特别是,如果F0(即在世之人)的环境暴露将通过表观遗传编程影响F2(即尚未出生之人)的健康,那么F1(即与F0和F2都重叠的在世之人)可能会在未来面临更高的成本来应对F2的健康状况:这可能会根据各种分配原则,如幸福平等机会原则,在F0身上产生义务。