• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

表观遗传学与后代

Epigenetics and Future Generations.

作者信息

Del Savio Lorenzo, Loi Michele, Stupka Elia

出版信息

Bioethics. 2015 Oct;29(8):580-7. doi: 10.1111/bioe.12150. Epub 2015 Feb 3.

DOI:10.1111/bioe.12150
PMID:25644664
Abstract

Recent evidence of intergenerational epigenetic programming of disease risk broadens the scope of public health preventive interventions to future generations, i.e. non existing people. Due to the transmission of epigenetic predispositions, lifestyles such as smoking or unhealthy diet might affect the health of populations across several generations. While public policy for the health of future generations can be justified through impersonal considerations, such as maximizing aggregate well-being, in this article we explore whether there are rights-based obligations supervening on intergenerational epigenetic programming despite the non-identity argument, which challenges this rationale in case of policies that affect the number and identity of future people. We propose that rights based obligations grounded in the interests of non-existing people might fall upon existing people when generations overlap. In particular, if environmental exposure in F0 (i.e. existing people) will affect the health of F2 (i.e. non-existing people) through epigenetic programming, then F1 (i.e. existing and overlapping with both F0 and F2) might face increased costs to address F2's condition in the future: this might generate obligations upon F0 from various distributive principles, such as the principle of equal opportunity for well being.

摘要

近期有关疾病风险的代际表观遗传编程的证据拓宽了公共卫生预防干预措施的范围,将其延伸至子孙后代,即尚未出生的人。由于表观遗传易感性的传递,吸烟或不健康饮食等生活方式可能会影响几代人群的健康。虽然可以通过非个人化的考量,如最大化总体福祉,来证明制定有利于子孙后代健康的公共政策的合理性,但在本文中,我们探讨了尽管存在非同一性论证(该论证在影响未来人口数量和身份的政策中对这一基本原理提出了挑战),基于权利的义务是否仍会在代际表观遗传编程中产生。我们提出,当世代重叠时,基于尚未出生之人利益的基于权利的义务可能会落在在世之人身上。特别是,如果F0(即在世之人)的环境暴露将通过表观遗传编程影响F2(即尚未出生之人)的健康,那么F1(即与F0和F2都重叠的在世之人)可能会在未来面临更高的成本来应对F2的健康状况:这可能会根据各种分配原则,如幸福平等机会原则,在F0身上产生义务。

相似文献

1
Epigenetics and Future Generations.表观遗传学与后代
Bioethics. 2015 Oct;29(8):580-7. doi: 10.1111/bioe.12150. Epub 2015 Feb 3.
2
The ambiguous nature of epigenetic responsibility.表观遗传责任的模糊性质。
J Med Ethics. 2016 Aug;42(8):534-41. doi: 10.1136/medethics-2015-103295. Epub 2016 Mar 25.
3
Voluntary health risks and public policy. 1. Taking risks, assessing responsibility.自愿性健康风险与公共政策。1. 承担风险,评估责任。
Hastings Cent Rep. 1981 Oct;11(5):26-31.
4
Genetic and metabolic determinants of human epigenetic variation.人类表观遗传变异的遗传和代谢决定因素。
Curr Opin Clin Nutr Metab Care. 2015 Jul;18(4):334-8. doi: 10.1097/MCO.0000000000000194.
5
Epigenetic exceptionalism.表观遗传例外论。
J Law Med Ethics. 2013 Fall;41(3):733-6. doi: 10.1111/jlme.12083.
6
Reflecting on Sacrifices Made by Past Generations Increases a Sense of Obligation Towards Future Generations.反思前人的牺牲,会增强对后代的责任感。
Pers Soc Psychol Bull. 2020 Jul;46(7):995-1012. doi: 10.1177/0146167219883610. Epub 2019 Nov 19.
7
Ethical implications of epigenetics in the era of personalized medicine.个体化医学时代的表观遗传学的伦理问题。
Clin Epigenetics. 2022 Mar 25;14(1):44. doi: 10.1186/s13148-022-01263-1.
8
From what should we protect future generations: germ-line therapy or genetic screening?我们应该保护后代免受什么影响:生殖系疗法还是基因筛查?
Med Health Care Philos. 2003;6(1):17-24. doi: 10.1023/a:1022588022876.
9
Whoopie pies, supersized fries. "Just" snacking? "Just" des(s)erts?奶油夹心饼,超大份薯条。这只是“随便”吃点零食?只是“随便”吃点甜点?
Camb Q Healthc Ethics. 2012 Jan;21(1):5-19. doi: 10.1017/S0963180111000454.
10
[Early determinants of health and disease: epigenetics and environment].[健康与疾病的早期决定因素:表观遗传学与环境]
Bull Acad Natl Med. 2011 Mar;195(3):511-26; discussion 526-7.

引用本文的文献

1
Epigenetics of Endometrial Cancer: The Role of Chromatin Modifications and Medicolegal Implications.子宫内膜癌的表观遗传学:染色质修饰的作用及法医学意义
Int J Mol Sci. 2025 Jul 29;26(15):7306. doi: 10.3390/ijms26157306.
2
The ethical aspects of exposome research: a systematic review.暴露组研究的伦理问题:一项系统综述。
Exposome. 2023 Apr 12;3(1):osad004. doi: 10.1093/exposome/osad004.
3
Meaning of Ambiguity: A Japanese Survey on Synthetic Biology and Genome Editing.歧义的含义:一项关于合成生物学与基因组编辑的日本调查
Front Sociol. 2019 Dec 17;4:81. doi: 10.3389/fsoc.2019.00081. eCollection 2019.
4
Epigenetics, ethics, law and society: A multidisciplinary review of descriptive, instrumental, dialectical and reflexive analyses.表观遗传学、伦理学、法律和社会:描述性、工具性、辩证性和反思性分析的多学科综述。
Soc Stud Sci. 2019 Oct;49(5):785-810. doi: 10.1177/0306312719866007. Epub 2019 Aug 1.
5
Epigenetics Changes Nothing: What a New Scientific Field Does and Does Not Mean for Ethics and Social Justice.表观遗传学没有改变任何东西:一个新的科学领域对伦理和社会正义意味着什么以及不意味着什么。
Public Health Ethics. 2017 Aug 14;11(1):69-81. doi: 10.1093/phe/phx013. eCollection 2018 Apr.
6
Transgenerational epigenetics and environmental justice.跨代表观遗传学与环境正义。
Environ Epigenet. 2017 Aug 3;3(3):dvx011. doi: 10.1093/eep/dvx011. eCollection 2017 Jul.
7
Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species.代际间长寿的非基因组传递:潜在机制及跨物种证据
Epigenetics Chromatin. 2017 Jul 27;10(1):38. doi: 10.1186/s13072-017-0145-1.
8
Health, wealth and behavioural change: an exploration of role responsibilities in the wake of epigenetics.健康、财富与行为改变:表观遗传学背景下角色责任的探讨
J Community Genet. 2018 Apr;9(2):153-167. doi: 10.1007/s12687-017-0315-7. Epub 2017 Jul 18.