Dalvie Deepak, Zientek Michael
Pfizer Global Research and Development, LaJolla Laboratories, San Diego.
Curr Protoc Toxicol. 2015 Feb 2;63:4.41.1-4.41.13. doi: 10.1002/0471140856.tx0441s63.
Aldehyde oxidase (AO) is a cytosolic molybdoflavoprotein whose contribution to the metabolism and clearance of xenobiotics-containing heterocyclic rings has attracted increased interest in recent years. This unit details methods for identification and confirmation of AO as a metabolic pathway as well as a method for estimating clearance of compounds that are AO substrates.
醛氧化酶（AO）是一种胞质钼黄素蛋白，近年来，其在含杂环的外源性物质代谢和清除中的作用引起了越来越多的关注。本单元详细介绍了将AO鉴定和确认为一种代谢途径的方法，以及一种估算AO底物化合物清除率的方法。
