Rudert M, Holzapfel B M, von Rottkay E, Holzapfel D E, Noeth U
Department of Orthopaedic Surgery, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, 97072, Wuerzburg, Germany,
Oper Orthop Traumatol. 2015 Feb;27(1):35-46. doi: 10.1007/s00064-014-0330-3. Epub 2015 Feb 4.
Regeneration of autologous bone stock and formation of a stable implant bed by impaction of morselized bone allograft.
Bone loss after septic and aseptic loosening or tumour resection.
Persistent infection, one-stage septic revision, poor therapeutic compliance, extensive uncontained metaphyseal defects with cortical thinning of the diaphysis.
Whilst the surgeon removes the loose prosthesis, the assistant prepares the graft. The medullary canal is sealed with a cement restrictor. Graft particles of different sizes are densely impacted around a trial stem. The highest level of stability is achieved by using large particles interspersed with small filler particles. Low-viscosity cement facilitates cement penetration and ensures strong interdigitation with the impacted graft mass after implantation of the prosthesis. Uncontained metaphyseal defects are treated with prosthetic augments.
Gait training, physiotherapy with isometric quadriceps exercises, partial weight-bearing for 6 weeks, resistance training begins 8 weeks postoperatively.
Between 2010 and 2012, 28 patients with large bone defects [Anderson Orthopaedic Research Institute (AORI) grade: 21 × F3, 3 × F2, 13 × T3, 8 × T2] underwent total knee revision with impaction bone grafting. The mean follow-up was 27.7 months (range 21-47 months). On average, patients had undergone 2.5 previous revisions. Implant survival was 82.0 % (95 % CI = 62.5 %-92.1 %) for any reason of revision as the endpoint and 93.1 % (95 % CI = 74.5-98.4 %) for aseptic revision as the endpoint. The mean postoperative Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score was 35.4 (range 3.3-101.6, SD ± 26.2). The mean KSS was 70.6 (range 20-100, SD ± 26.8).
通过嵌压异体碎骨移植实现自体骨储备再生并形成稳定的植入床。
感染性和无菌性松动或肿瘤切除术后的骨缺损。
持续感染、一期感染性翻修、治疗依从性差、广泛的无包壳干骺端缺损且骨干皮质变薄。
在外科医生移除松动假体的同时,助手准备移植物。用骨水泥限制器封闭髓腔。不同大小的移植物颗粒紧密嵌压在试验柄周围。通过使用大颗粒与小填充颗粒相间的方式可实现最高水平的稳定性。低粘度骨水泥有助于骨水泥渗透,并确保在假体植入后与嵌压的移植物团块形成牢固的相互交锁。无包壳的干骺端缺损用假体增强物治疗。
步态训练、等长股四头肌锻炼的物理治疗、6周部分负重,术后8周开始抗阻训练。
2010年至2012年期间,28例大骨缺损患者[安德森矫形研究所(AORI)分级:21例×F3、3例×F2、13例×T3、8例×T2]接受了全膝关节翻修并进行嵌压植骨。平均随访27.7个月(范围21 - 47个月)。患者平均之前接受过2.5次翻修。以任何翻修原因作为终点,植入物生存率为82.0%(95%CI = 62.5% - 92.1%);以无菌性翻修为终点,植入物生存率为93.1%(95%CI = 74.5 - 98.4%)。术后平均西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分为35.4(范围3.3 - 101.6,标准差±26.2)。平均膝关节协会评分(KSS)为70.6(范围20 - 100,标准差±26.8)。