慢性移植物抗宿主病中异常的B细胞稳态。
Aberrant B-cell homeostasis in chronic GVHD.
作者信息
Sarantopoulos Stefanie, Ritz Jerome
机构信息
Division of Cell Therapy and Hematologic Malignancies, Department of Medicine, Duke Cancer Institute, Duke University, Durham, NC; and.
Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
出版信息
Blood. 2015 Mar 12;125(11):1703-7. doi: 10.1182/blood-2014-12-567834. Epub 2015 Feb 2.
Abstract
Recent studies have compelled further interest in the potential pathological role of B cells in chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated and primed for survival via B-cell activating factor and B-cell receptor-associated pathways. Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate the development of new strategies to selectively target aberrantly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantation.
摘要
最近的研究引发了人们对B细胞在慢性移植物抗宿主病（cGVHD）中潜在病理作用的进一步关注。在cGVHD患者中，B细胞通过B细胞活化因子和B细胞受体相关途径被激活并为生存做好准备。了解驱动cGVHD免疫病理的信号通路将有助于开发新策略，以选择性地靶向异常激活的B细胞，并在异基因干细胞移植后恢复正常的B细胞内环境稳定。
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