Yamada Ichiro, Miyasaka Naoyuki, Hikishima Keigo, Tokairin Yutaka, Kawano Tatsuyuki, Ito Eisaku, Kobayashi Daisuke, Eishi Yoshinobu, Okano Hideyuki
Department of Diagnostic Radiology and Oncology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Magn Reson Imaging. 2015 May;33(4):413-9. doi: 10.1016/j.mri.2014.11.005. Epub 2015 Jan 30.
To determine the usefulness of ultra-high-resolution magnetic resonance (MR) imaging at an ultra-high field strength (7.0T), using a voxel volume of 9.5-14nL, as means of evaluating the depth of mural invasion by esophageal carcinomas.
Twenty esophageal specimens containing 20 carcinomas were studied using a 7.0-T MR imaging system with a four-channel surface coil. Ultra-high-resolution MR images were obtained with a field of view of 50-60mm×25-30mm, a matrix of 512×256, and a section thickness of 1.0mm, resulting in a voxel volume of 0.0095-0.014mm(3) (9.5-14nL). Differences between tumor tissue and the esophageal wall layers and between tumor tissue and fibrosis were evaluated using visual signal intensity scoring measurements. MR images were then compared with histopathologic findings as the reference standard.
Ultra-high-resolution T2-weighted MR images at 7.0T clearly depicted the normal esophageal wall in all 20 specimens (100%) as consisting of eight layers, which clearly corresponded to the tissue layers of the esophageal wall. Ultra-high-resolution T2-weighted MR images made it possible to differentiate between the tumor tissue and fibrosis clearly (P<0.01). In all 20 esophageal carcinomas (100%), ultra-high-resolution T2-weighted MR images made it possible to determine the depth of tumor invasion in the esophageal wall as observed in the histopathologic sections. Regional lymph node involvement was also clearly depicted in four specimens.
Ultra-high-resolution 7.0-T MR imaging, using a voxel volume of 9.5-14nL, provides clear delineation of the esophageal wall layers, clear differentiation of tumor tissue from fibrosis, and excellent diagnostic accuracy for evaluating mural invasion by esophageal carcinomas.
使用体素体积为9.5 - 14nL的超高场强（7.0T）超高分辨率磁共振（MR）成像，作为评估食管癌壁内浸润深度的手段，确定其效用。
使用带有四通道表面线圈的7.0T MR成像系统，对20个含有20处癌灶的食管标本进行研究。获取超高分辨率MR图像，视野为50 - 60mm×25 - 30mm，矩阵为512×256，层厚为1.0mm，从而得到体素体积为0.0095 - 0.014mm³（9.5 - 14nL）。通过视觉信号强度评分测量，评估肿瘤组织与食管壁各层之间以及肿瘤组织与纤维化之间的差异。然后将MR图像与作为参考标准的组织病理学结果进行比较。
7.0T超高分辨率T2加权MR图像在所有20个标本（100%）中清晰显示正常食管壁由八层组成，这与食管壁的组织层明显对应。超高分辨率T2加权MR图像能够清晰区分肿瘤组织与纤维化（P<0.01）。在所有20例食管癌（100%）中，超高分辨率T2加权MR图像能够确定食管壁内肿瘤浸润的深度，如同在组织病理学切片中观察到的那样。在四个标本中还清晰显示了区域淋巴结受累情况。
使用体素体积为9.5 - 14nL的7.0T超高分辨率MR成像，能够清晰描绘食管壁各层，清晰区分肿瘤组织与纤维化，并且在评估食管癌壁内浸润方面具有出色的诊断准确性。
