Creighton F J, Ghodse A H
Department of Adult Phychiatry, Withington Hospital, Manchester, London.
Lancet. 1989 Apr 8;1(8641):748-50. doi: 10.1016/s0140-6736(89)92573-7.
Significant pupillary dilatation in response to conjunctivally applied naloxone was demonstrated with polaroid photography in 46 opiate addicts on maintenance methadone prescription. No pupillary response was seen to an identical procedure in 17 non-addict subjects who had been given an opiate premedication before elective surgery. This pupillary response to naloxone could be used as a test to identify the physically dependent opiate user.
通过宝丽来摄影显示，46名接受美沙酮维持治疗的阿片类药物成瘾者对结膜应用纳洛酮有明显的瞳孔散大。17名在择期手术前接受阿片类药物术前用药的非成瘾受试者在相同操作下未出现瞳孔反应。这种对纳洛酮的瞳孔反应可作为一种检测方法来识别身体依赖阿片类药物的使用者。
