稳定期肝移植受者体内的半乳糖凝集素-1
Galectin-1 in stable liver transplant recipients.
作者信息
García M J, Jurado F, San Segundo D, López-Hoyos M, Iruzubieta P, Llerena S, Casafont F, Arias M, Puente Á, Crespo J, Fábrega E
机构信息
Gastroenterology and Hepatology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain; Instituto de Investigación Márqués de Valdecilla (IDIVAL), Santander, Spain.
Instituto de Investigación Márqués de Valdecilla (IDIVAL), Santander, Spain; Immunology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain.
出版信息
Transplant Proc. 2015 Jan-Feb;47(1):93-6. doi: 10.1016/j.transproceed.2014.12.001.
INTRODUCTION
The achievement of a state of tolerance and minimization of the immunosuppressive load form part of the "Holy Grail" in solid organ transplantation. Galectin-1 recently has been described to be involved in the maintenance of a tolerant environment, but there is no evidence of its role in human liver transplantation. The aim of our study was to measure the serum levels of galectin-1 in stable liver transplant recipients.
METHODS
Serum levels of galectin-1 were determined in 30 stable liver transplant recipients who had been free of rejection episodes for at least 8 years. Fifteen patients with an acute rejection episode and 34 healthy subjects were used as the control group.
RESULTS
The concentrations of galectin-1 were significantly higher in stable liver transplant recipients compared with healthy subjects and with the acute rejection group.
CONCLUSIONS
These preliminary results indicate that galectin-1 is upregulated in stable liver transplant recipients. Thus, our results extend the recent findings that galectin-1 may play an immune-suppressive role in liver transplantation. It remains to be established whether it might help to induce tolerance in liver transplantation.
引言
实现免疫耐受状态并将免疫抑制负荷降至最低是实体器官移植领域的“圣杯”目标之一。近期研究表明半乳糖凝集素-1参与维持免疫耐受环境，但尚无证据表明其在人类肝移植中的作用。本研究旨在测定稳定期肝移植受者血清中半乳糖凝集素-1的水平。
方法
选取30例至少8年未发生排斥反应的稳定期肝移植受者，测定其血清半乳糖凝集素-1水平。选取15例发生急性排斥反应的患者和34例健康受试者作为对照组。
结果
与健康受试者及急性排斥反应组相比，稳定期肝移植受者血清半乳糖凝集素-1浓度显著升高。
结论
这些初步结果表明，稳定期肝移植受者体内半乳糖凝集素-1上调。因此，我们的研究结果扩展了近期关于半乳糖凝集素-1可能在肝移植中发挥免疫抑制作用的发现。半乳糖凝集素-1是否有助于诱导肝移植中的免疫耐受仍有待确定。
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