发育生物学。肠道干细胞的区域特性——一个基因统领全局。
Developmental biology. Regional identity of gut stem cells--one gene to rule them all.
机构信息
Division of Developmental Biology and Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
出版信息
Nat Rev Gastroenterol Hepatol. 2015 Mar;12(3):125-6. doi: 10.1038/nrgastro.2015.22. Epub 2015 Feb 3.
PMID:25645971
Abstract
The stem cells in the stomach and intestine are regulated by different signalling pathways and give rise to entirely different specialized lineages. A study by Simmini and colleagues suggests that the organ-specific identity of gastrointestinal stem cells is regulated by one transcription factor, Cdx2.
摘要
胃和肠道中的干细胞受不同信号通路的调控，并产生完全不同的特化谱系。Simmini 及其同事的一项研究表明，胃肠道干细胞的器官特异性由一个转录因子 Cdx2 调控。
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