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发育生物学。肠道干细胞的区域特性——一个基因统领全局。

Developmental biology. Regional identity of gut stem cells--one gene to rule them all.

机构信息

Division of Developmental Biology and Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

出版信息

Nat Rev Gastroenterol Hepatol. 2015 Mar;12(3):125-6. doi: 10.1038/nrgastro.2015.22. Epub 2015 Feb 3.

DOI:10.1038/nrgastro.2015.22
PMID:25645971
Abstract

The stem cells in the stomach and intestine are regulated by different signalling pathways and give rise to entirely different specialized lineages. A study by Simmini and colleagues suggests that the organ-specific identity of gastrointestinal stem cells is regulated by one transcription factor, Cdx2.

摘要

胃和肠道中的干细胞受不同信号通路的调控，并产生完全不同的特化谱系。Simmini 及其同事的一项研究表明，胃肠道干细胞的器官特异性由一个转录因子 Cdx2 调控。

相似文献

1
Developmental biology. Regional identity of gut stem cells--one gene to rule them all.发育生物学。肠道干细胞的区域特性——一个基因统领全局。
Nat Rev Gastroenterol Hepatol. 2015 Mar;12(3):125-6. doi: 10.1038/nrgastro.2015.22. Epub 2015 Feb 3.
2
Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.转录因子Cdx2缺失时肠道干细胞向胃干细胞的转化
Nat Commun. 2014 Dec 11;5:5728. doi: 10.1038/ncomms6728.
3
CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.CDX1 通过诱导干性相关重编程因子 SALL4 和 KLF5 赋予胃上皮细胞肠表型。
Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20584-9. doi: 10.1073/pnas.1208651109. Epub 2012 Oct 29.
4
Expression of Claudin-2 in intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach.Claudin-2在Cdx2转基因小鼠胃肠化生黏膜中的表达
Scand J Gastroenterol. 2010 Nov;45(11):1273-80. doi: 10.3109/00365521.2010.501522. Epub 2010 Jul 5.
5
The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1.肠道特异性同源盒基因Cdx2可诱导碱性螺旋-环-螺旋转录因子Math1的表达。
Differentiation. 2006 Jul;74(6):313-21. doi: 10.1111/j.1432-0436.2006.00074.x.
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Cdx2 initiates histodifferentiation of the midgut endoderm.Cdx2启动中肠内胚层的组织分化。
FEBS Lett. 2008 Jul 23;582(17):2555-60. doi: 10.1016/j.febslet.2008.06.024. Epub 2008 Jun 23.
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SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype.SOX2 将肠上皮的发育命运重定向为早期胃表型。
J Mol Cell Biol. 2012 Dec;4(6):377-85. doi: 10.1093/jmcb/mjs030. Epub 2012 Jun 7.
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Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach.Cdx1和Cdx2 mRNA的表达及其与人类胃肠道黏膜分化的相关性——特别强调其在人胃肠化生中的作用
Gastric Cancer. 2001;4(4):185-91. doi: 10.1007/pl00011741.
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Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia.胃转录因子Sox2的下调以及肠同源盒基因Cdx1和Cdx2的异位表达：从胃/肠混合化生到完全肠化生进展过程中的负相关。
J Cancer Res Clin Oncol. 2004 Mar;130(3):135-45. doi: 10.1007/s00432-003-0519-6. Epub 2003 Dec 4.

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本文引用的文献

1
Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.转录因子Cdx2缺失时肠道干细胞向胃干细胞的转化
Nat Commun. 2014 Dec 11;5:5728. doi: 10.1038/ncomms6728.
2
CDX2 can be regulated through the signalling pathways activated by IL-6 in gastric cells.CDX2可通过胃细胞中由IL-6激活的信号通路进行调控。
Biochim Biophys Acta. 2014 Sep;1839(9):785-92. doi: 10.1016/j.bbagrm.2014.06.009. Epub 2014 Jun 19.
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Adult stem cells in the small intestine are intrinsically programmed with their location-specific function.
Development. 2017 Mar 1;144(5):755-766. doi: 10.1242/dev.143784.
小肠中的成体干细胞在本质上被编程为具有其特定位置的功能。
Stem Cells. 2014 May;32(5):1083-91. doi: 10.1002/stem.1655.
4
Gastric intestinal metaplasia revisited: function and regulation of CDX2.胃肠上皮化生再探讨：CDX2 的功能与调控。
Trends Mol Med. 2012 Sep;18(9):555-63. doi: 10.1016/j.molmed.2012.07.006. Epub 2012 Aug 4.
5
SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype.SOX2 将肠上皮的发育命运重定向为早期胃表型。
J Mol Cell Biol. 2012 Dec;4(6):377-85. doi: 10.1093/jmcb/mjs030. Epub 2012 Jun 7.
6
Cdx2 determines the fate of postnatal intestinal endoderm.Cdx2 决定了出生后肠道内胚层的命运。
Development. 2012 Feb;139(3):465-74. doi: 10.1242/dev.070722. Epub 2011 Dec 21.
7
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.Sox2(+) 成年干细胞和祖细胞对小鼠的组织再生和存活很重要。
Cell Stem Cell. 2011 Oct 4;9(4):317-29. doi: 10.1016/j.stem.2011.09.001.
8
Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2.通过Cdx2建立肠道特征及上皮-间充质信号传导。
Dev Cell. 2009 Apr;16(4):588-99. doi: 10.1016/j.devcel.2009.02.010.
9
The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster.副同源盒基因簇是同源盒基因簇在进化上的姐妹。
Nature. 1998 Apr 30;392(6679):920-2. doi: 10.1038/31933.
10
Homeosis and intestinal tumours in Cdx2 mutant mice.Cdx2突变小鼠中的同源异型现象与肠道肿瘤
Nature. 1997 Mar 6;386(6620):84-7. doi: 10.1038/386084a0.