Phadke Keerti V, Manjeshwar Lata S, Aminabhavi Tejraj M
Department of Chemistry, Karnatak University, Dharwad 580 003, India.
Department of Chemistry, Karnatak University, Dharwad 580 003, India.
Int J Biol Macromol. 2015 Apr;75:505-14. doi: 10.1016/j.ijbiomac.2015.01.045. Epub 2015 Jan 31.
Water-soluble acrylamide (AAm)-grafted-chitosan (CS) copolymer (AAm-g-CS) was synthesized using potassium persulfate (PPS) initiator from which interpenetrating polymer network (IPN) microspheres were prepared by water-in-oil (w/o) emulsion that are cross-linked with glutaraldehyde (GA) and used for encapsulating nifedipine (NFD). Microspheres were coated with sodium alginate (NaAlg) to enhance their pH-sensitivity for extending the release time of NFD up to 14 h, releasing with 93% of NFD. The coated and uncoated microspheres were characterized by Fourier transform infrared spectra (FTIR) and differential scanning calorimetry (DSC) to understand chemical interactions and blend compatibility. Morphology and particle size of the microspheres were assessed by scanning electron microscopy (SEM) and particle zeta analyzer, respectively. Swelling and in vitro release experiments were performed in pH 1.2 and 7.4 buffer media, which showed a dependence on IPN blend composition, extent of cross-linking and amount of AAm used. Empirical analysis of drug patterns suggested the differences between NaAlg coated and uncoated microspheres.
采用过硫酸钾（PPS）引发剂合成了水溶性丙烯酰胺（AAm）接枝壳聚糖（CS）共聚物（AAm-g-CS），通过油包水（w/o）乳液制备了互穿聚合物网络（IPN）微球，该微球用戊二醛（GA）交联并用于包封硝苯地平（NFD）。微球用海藻酸钠（NaAlg）包衣以增强其pH敏感性，将NFD的释放时间延长至14小时，NFD释放率为93%。通过傅里叶变换红外光谱（FTIR）和差示扫描量热法（DSC）对包衣和未包衣的微球进行表征，以了解化学相互作用和共混相容性。分别通过扫描电子显微镜（SEM）和颗粒zeta分析仪评估微球的形态和粒径。在pH 1.2和7.4缓冲介质中进行了溶胀和体外释放实验，结果表明其依赖于IPN共混物组成、交联程度和AAm用量。药物释放模式的实证分析表明了NaAlg包衣和未包衣微球之间的差异。
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