Li Weina, Wu Nan, Hou Wensheng, Zhang Jiuquan, Xu Wenxin, Wu Guocai, Zheng Xiaolin, Feng Hua
*Bioengineering College, Chongqing University, Chongqing, China; and Departments of †Neurosurgery and ‡Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
J Clin Neurophysiol. 2015 Feb;32(1):57-65. doi: 10.1097/WNP.0000000000000120.
The purpose of this work was to find an objective and quantitative method for epileptic foci lateralization that may aid and support the decision made by the usually chosen lateralizing criteria.
A frequency-derived causal analysis method, full frequency adaptive directed transfer function, was applied to the interictal scalp EEG data collected from 2 groups of total 30 epileptic patients. Group A included 15 refractory epileptic patients who had undergone an epileptic surgery; group B consisted of 15 outpatient epileptic patients who had a seizure type of generalized tonic-clonic seizure. All patients had no abnormalities detected in their routine brain MRI examinations. The methodology that leads to the lateralization is based on several processing steps: interictal spikes selection, full frequency adaptive directed transfer function analysis, significant causal connections extraction, and then lateralization.
Ninety-six of 104 spikes' sources lateralized by full frequency adaptive directed transfer function were consistent with their corresponding surgery side in group A, with the accuracy of 92.31%. Ninety-seven of 101 spikes' sources were lateralized correctly in group B, according to technicians' judgments from ictal scalp video-EEG recordings, with the accuracy of 96.04%.
The results demonstrated the feasibility of correctly lateralizing the epileptic foci by using full frequency adaptive directed transfer function to scalp EEG interictal spike activity.
本研究旨在寻找一种客观、定量的癫痫病灶侧化方法，以辅助并支持通常所采用的侧化标准所做出的决策。
将一种基于频率的因果分析方法——全频率自适应定向传递函数，应用于从两组共30例癫痫患者收集的发作间期头皮脑电图数据。A组包括15例接受过癫痫手术的难治性癫痫患者；B组由15例发作类型为全身强直阵挛发作的门诊癫痫患者组成。所有患者在常规脑磁共振成像检查中均未发现异常。导致侧化的方法基于几个处理步骤：发作间期棘波选择、全频率自适应定向传递函数分析、显著因果连接提取，然后进行侧化。
A组中，通过全频率自适应定向传递函数侧化的104个棘波源中有96个与其相应的手术侧一致，准确率为92.31%。根据技术人员对发作期头皮视频脑电图记录的判断，B组中101个棘波源中有97个侧化正确，准确率为96.04%。
结果表明，利用全频率自适应定向传递函数对头皮脑电图发作间期棘波活动进行癫痫病灶侧化是可行的。
