Thengilsdóttir G, Pottegård A, Linnet K, Halldórsson M, Almarsdóttir A B, Gardarsdóttir H
Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavík, Iceland.
Int J Clin Pract. 2015 May;69(5):597-603. doi: 10.1111/ijcp.12558. Epub 2015 Feb 4.
Primary non-adherence occurs when a drug has been prescribed but the patient fails to have it dispensed at the pharmacy.
To assess primary non-adherence to statins and antidepressants in Iceland, the association of demographic factors with primary non-adherence, and the time from when a prescription is issued until it is dispensed.
Data on patients receiving a new prescription for a statin or an antidepressant from the Primary Health Care database were linked with dispensing histories from The Icelandic Prescription Database. The proportion of patients who did not have their prescription dispensed within a year from issuing (primary non-adherent) was assessed, as well as the time from issue until dispensing. Associations between demographic factors and primary non-adherence were estimated using logistic regression.
The overall primary non-adherence was 6.3% and 8.0% for statins and antidepressants, respectively. The majority of patients had their prescription dispensed within 7 days (85% for statins, 87% for antidepressants). Being disabled and receiving a prescription for an expensive drug was associated with higher rates of primary non-adherence.
The rate of primary non-adherence to statins and antidepressants in Iceland is low. Vulnerable groups such as the disabled should be given special attention when new drugs are prescribed.
原发性不依从是指药物已被处方，但患者未在药房取药。
评估冰岛他汀类药物和抗抑郁药物的原发性不依从情况、人口统计学因素与原发性不依从之间的关联，以及从处方开具到取药的时间。
将初级卫生保健数据库中接受他汀类药物或抗抑郁药物新处方的患者数据与冰岛处方数据库中的配药记录相链接。评估在处方开具后一年内未取药（原发性不依从）的患者比例，以及从开具到取药的时间。使用逻辑回归估计人口统计学因素与原发性不依从之间的关联。
他汀类药物和抗抑郁药物的总体原发性不依从率分别为6.3%和8.0%。大多数患者在7天内取药（他汀类药物为85%，抗抑郁药物为87%）。残疾以及接受昂贵药物处方与较高的原发性不依从率相关。
冰岛他汀类药物和抗抑郁药物的原发性不依从率较低。在开具新药时，应特别关注残疾等弱势群体。
