Moyer Tyson J, Kassam Hussein A, Bahnson Edward S M, Morgan Courtney E, Tantakitti Faifan, Chew Teng L, Kibbe Melina R, Stupp Samuel I
Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.
Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA.
Small. 2015 Jun;11(23):2750-5. doi: 10.1002/smll.201403429. Epub 2015 Feb 3.
Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.
本文描述了在球囊血管成形术后通过全身递送超分子纳米纤维进行血管介入靶向治疗的情况。利用荧光对自组装肽两亲分子进行追踪,结果显示其能选择性地结合到血管介入部位。观察到圆柱形纳米结构靶向动脉损伤部位,而具有相同直径的球形纳米结构则无结合现象。