Wolf-Dieter R, Heuschneider G, Sperk G, Riederer P
Institute for Medical Chemistry, Veterinary Medical University, Vienna, Austria.
Metab Brain Dis. 1989 Mar;4(1):3-7. doi: 10.1007/BF00999487.
The Mongolian gerbil, with its spontaneous epileptiform seizures, was chosen as an experimental model of human epilepsy. Neurochemical parameters possibly related to the seizure process were studied. In the immediate seizure process amino acid profiles of cortex, hippocampus, and striatum were not different in seizuring animals when compared to seizure-resistance controls. Of two peptides analyzed, only somatostatin appeared elevated in the cortex 2 hr postictal (143 fmol/mg protein; controls, 123 fmol/mg protein); neuropeptide Y was not affected. A follow up of the time course of cyclic AMP and cyclic GMP showed significant elevations of both substances as a consequence of seizures. Most prominent was a 5.5-fold increase in cyclic GMP in the cerebellum 30 sec after seizure onset.
蒙古沙鼠因其自发性癫痫样发作，被选作人类癫痫的实验模型。对可能与癫痫发作过程相关的神经化学参数进行了研究。在癫痫发作的即时过程中，与抗癫痫对照组相比，发作动物的皮质、海马和纹状体的氨基酸谱并无差异。在分析的两种肽中，只有生长抑素在发作后2小时的皮质中出现升高（143 fmol/mg蛋白质；对照组为123 fmol/mg蛋白质）；神经肽Y未受影响。对环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）时间进程的后续研究表明，癫痫发作导致这两种物质均显著升高。最显著的是癫痫发作开始后30秒，小脑内的cGMP增加了5.5倍。
