Li Jing, Kim Kyungho, Barazia Andrew, Tseng Alan, Cho Jaehyung
Department of Pharmacology, University of Illinois College of Medicine, 835 S. Wolcott Ave, E403, Chicago, IL, 60612, USA.
Cell Mol Life Sci. 2015 Jul;72(14):2627-43. doi: 10.1007/s00018-015-1845-y. Epub 2015 Feb 4.
Platelets primarily mediate hemostasis and thrombosis, whereas leukocytes are responsible for immune responses. Since platelets interact with leukocytes at the site of vascular injury, thrombosis and vascular inflammation are closely intertwined and occur consecutively. Recent studies using real-time imaging technology demonstrated that platelet-neutrophil interactions on the activated endothelium are an important determinant of microvascular occlusion during thromboinflammatory disease in which inflammation is coupled to thrombosis. Although the major receptors and counter receptors have been identified, it remains poorly understood how heterotypic platelet-neutrophil interactions are regulated under disease conditions. This review discusses our current understanding of the regulatory mechanisms of platelet-neutrophil interactions in thromboinflammatory disease.
血小板主要介导止血和血栓形成，而白细胞负责免疫反应。由于血小板在血管损伤部位与白细胞相互作用，血栓形成和血管炎症紧密相连且相继发生。最近使用实时成像技术的研究表明，在炎症与血栓形成相关联的血栓炎症性疾病中，活化内皮细胞上的血小板 - 中性粒细胞相互作用是微血管阻塞的重要决定因素。尽管主要的受体和反受体已被确定，但在疾病状态下异型血小板 - 中性粒细胞相互作用是如何被调节的仍知之甚少。本综述讨论了我们目前对血栓炎症性疾病中血小板 - 中性粒细胞相互作用调节机制的理解。
