诱导抗胚胎化免疫对日本血吸虫感染小鼠肝脏肉芽肿、脾脏重量和门静脉压力的影响。

Effects of induction of anti-embryonation immunity on liver granulomas, spleen weight and portal pressure in mice infected with Schistosoma japonicum.

作者信息

Garcia E G, Rivera P T, Mitchell G F, Evardome R R, Almonte R E, Tiu W U

机构信息

Department of Parasitology, College of Public Health, University of the Philippines, Manila.

出版信息

Acta Trop. 1989 Mar;46(2):93-9. doi: 10.1016/0001-706x(89)90002-8.

DOI:10.1016/0001-706x(89)90002-8

PMID:2565075

Abstract

BALB/c mice sensitized with injections of viable immature Schistosoma japonicum eggs had significantly fewer and smaller granulomas in the liver, lower portal pressure and smaller spleens at D + 75 of infection compared to similarly infected unsensitized controls. The portal pressure and spleen weights of the mice sensitized with immature eggs were not different from uninfected unsensitized mice of similar ages at D + 75 of infection. The results strongly support our hypothesis that it should be possible to prevent serious hepatosplenic disease in schistosomiasis japonica by vaccination to induce anti-embryonation immunity.

摘要

与同样感染但未致敏的对照组相比，通过注射活的未成熟日本血吸虫卵致敏的BALB/c小鼠在感染后第75天肝脏中的肉芽肿明显更少、更小，门静脉压力更低，脾脏更小。在感染后第75天，用未成熟卵致敏的小鼠的门静脉压力和脾脏重量与年龄相似的未感染未致敏小鼠没有差异。这些结果有力地支持了我们的假设，即通过接种疫苗诱导抗胚胎发育免疫来预防日本血吸虫病严重肝脾疾病应该是可行的。