*Department of Ophthalmology, The University of Tokyo †Yotsuya Shirato Eye Clinic, Tokyo, Japan.
J Glaucoma. 2015 Mar;24(3):225-32. doi: 10.1097/IJG.0000000000000219.
To examine the medium-term outcomes of fornix-based trabeculectomy (TLE) performed by a single surgeon and to analyze outcome in 3 glaucoma subtypes.
Consecutive prospective case series study to examine the 6-month outcome of 106 eyes [primary open-angle glaucoma (OAG), exfoliation glaucoma (XFG), and inflammatory glaucoma (ING)] that underwent TLE with mitomycin C performed by a single surgeon from September 2009 to September 2010 at Tokyo University Hospital. Main outcome measure was survival rates of targeted intraocular pressure (IOP) after TLE. Postoperative complications and procedures were analyzed according to glaucoma subtypes. Life table analyses were then made according to 2 criteria of failure: (1) IOP was >12 mm Hg with or without the use of topical glaucoma medications after 2 consecutive measurements or another surgery was needed; and (2) IOP was >15 mm Hg.
A total of 106 eyes, which consisted of 67 OAG eyes, 23 XFG eyes, 16 ING eyes, were analyzed for 6 months after TLE. Four eyes were reoperated. During and after hospitalization, complications were equally observed and procedures were equally performed in all of the 3 groups. For the first definition, cumulative survival rates at 6 months after surgery in OAG, XFG, and ING cases were 76.0%, 73.9%, and 62.5%, respectively. For the second definition, cumulative survival rates in OAG, XFG, and ING cases were 88.0%, 78.3%, and 68.8%, respectively.
Six-month outcome of TLE with a fornix-based conjunctival incision by a single surgeon that targeted an IOP<12 mm Hg was not different among 3 types of glaucoma.
研究由一位外科医生行穹窿部为基底的小梁切除术（TLE）的中期结果，并分析 3 种青光眼亚型的结果。
对 2009 年 9 月至 2010 年 9 月间由一位外科医生行穹窿部为基底的含丝裂霉素 C 的 TLE 治疗的 106 只眼（原发性开角型青光眼（OAG）、剥脱性青光眼（XFG）和炎症性青光眼（ING））的 6 个月结果进行连续前瞻性病例系列研究。主要观察指标为 TLE 后目标眼压（IOP）的生存率。根据青光眼亚型分析术后并发症和手术。然后根据 2 种失败标准（1：连续 2 次测量或需要另一次手术时 IOP>12mmHg，同时伴有或不伴有局部降眼压药物；2：IOP>15mmHg）进行寿命表分析。
共有 106 只眼（67 只 OAG 眼、23 只 XFG 眼、16 只 ING 眼）进行了 TLE 后 6 个月的分析。有 4 只眼需要再次手术。在住院期间和之后，所有 3 组的并发症发生率和手术处理均相同。对于第一个定义，OAG、XFG 和 ING 病例手术后 6 个月的累积生存率分别为 76.0%、73.9%和 62.5%。对于第二个定义，OAG、XFG 和 ING 病例的累积生存率分别为 88.0%、78.3%和 68.8%。
由一位外科医生行穹窿部为基底的结膜切口 TLE，目标眼压<12mmHg，在 3 种类型的青光眼之间，6 个月的结果无差异。
