骨内样本可用于肌酐测量——一项在麻醉猪身上的实验研究。
Intraosseous samples can be used for creatinine measurements--an experimental study in the anaesthetised pig.
作者信息
Strandberg Gunnar, Lipcsey Miklós, Eriksson Mats, Larsson Anders
出版信息
Clin Lab. 2014;60(10):1587-91. doi: 10.7754/clin.lab.2013.130911.
BACKGROUND
Intraosseous (IO) access is a valuable tool in prehospital locations and in emergency departments when other forms of vascular access are unavailable. Creatinine is often used for dose adjustment of drugs that may be administered through intraosseous cannulae. We aimed to study the possibility of analysing creatinine in intraosseous samples and study the accuracy and precision of such measurements.
METHODS
Eight pigs with endotoxin induced septic shock were sampled hourly for six hours and analysed for plasma creatinine. Samples were collected from arterial, venous, and IO cannulae.
RESULTS
There was an increase in creatinine values during the later part of the experiment. The coefficients of variation between the three sampling sites were less than 10% at all sampling times.
CONCLUSIONS
Based on our findings intraosseous samples can be used for creatinine determination in emergency settings.
背景
当无法采用其他形式的血管通路时，骨内（IO）通路是院前场所和急诊科的一项重要工具。肌酐常用于调整可能通过骨内套管给药的药物剂量。我们旨在研究分析骨内样本中肌酐的可能性，并研究此类测量的准确性和精密度。
方法
对八只内毒素诱导的感染性休克猪每小时采样一次，持续六小时，并分析血浆肌酐。样本从动脉、静脉和骨内套管采集。
结果
实验后期肌酐值有所升高。在所有采样时间，三个采样部位之间的变异系数均小于10%。
结论
基于我们的研究结果，骨内样本可用于紧急情况下的肌酐测定。
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