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Effect of alpha-2 adrenergic receptor stimulation on short-circuit current across isolated skin of the toad Bufo arenarum.

作者信息

Gamundi S S, Proto M C, Coviello A

机构信息

Department of Physiology, INSIBIO (CONICET-UNT), San Miguel de Tucumán, Argentina.

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;92(2):167-70. doi: 10.1016/0742-8413(89)90034-0.

DOI:10.1016/0742-8413(89)90034-0
PMID:2565178
Abstract
  1. The effect of the alpha-2 adrenergic agonist clonidine on short-circuit current (SCC) across isolated skins of Bufo arenarum toads was investigated. 2. Clonidine inhibited basal SCC in a dose-dependent manner. 3. Blockade of the effect of clonidine on basal SCC by the selective alpha-2 antagonist yohimbine supports the hypothesis that the inhibitory effect is mediated by the stimulation of alpha-2 adrenergic receptors. 4. The fact that the inhibitory effect of clonidine is higher in skins with spontaneous positive SCC than in the negative ones, and that the alpha-2 agonist was unable to alter amiloride-induced negative SCC suggests that the inhibitory effect of clonidine may probably be mediated by inhibition of sodium transport.
摘要

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