使用静息态MRI研究感音神经性听力损失患者的功能连接性。
Functional Connectivity in Patients With Sensorineural Hearing Loss Using Resting-State MRI.
作者信息
Liu Bin, Feng Yuan, Yang Ming, Chen Jing-ya, Li Jing, Huang Zhi-chun, Zhang Ling-ling
出版信息
Am J Audiol. 2015 Jun;24(2):145-52. doi: 10.1044/2015_AJA-13-0068.
PURPOSE
This study was undertaken to evaluate whole-brain functional connectivity changes related to auditory cortex in patients with left-sided sensorineural hearing loss (SNHL) using resting-state functional connectivity magnetic resonance imaging.
METHOD
Imaging was performed in 19 patients with left-sided SNHL and 35 individuals in the control group without SNHL. Data were collected and analyzed to map functional connectivity using the left/right primary auditory cortex as the region of interest to identify global differences between patients with SNHL and the control group.
RESULTS
In comparison to the control group, the SNHL group was found to have significant functional connectivity changes in the auditory system, recognition network, visual cortex, and language network.
CONCLUSION
These findings suggest that functional brain alterations in unilateral SNHL patients may indicate reorganizations that occur in response to auditory deficits.
目的
本研究旨在使用静息态功能连接磁共振成像评估左侧感音神经性听力损失（SNHL）患者与听觉皮层相关的全脑功能连接变化。
方法
对19例左侧SNHL患者和35名无SNHL的对照组个体进行成像。收集并分析数据，以左/右初级听觉皮层作为感兴趣区域来绘制功能连接，以识别SNHL患者与对照组之间的整体差异。
结果
与对照组相比，发现SNHL组在听觉系统、认知网络、视觉皮层和语言网络中存在显著的功能连接变化。
结论
这些发现表明，单侧SNHL患者的脑功能改变可能表明是对听觉缺陷做出反应而发生的重组。
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