Ben Jingjing, Zhu Xudong, Zhang Hanwen, Chen Qi
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, 210029, China.
Br J Pharmacol. 2015 Dec;172(23):5523-30. doi: 10.1111/bph.13105. Epub 2015 Mar 27.
Class A1 scavenger receptors (SR-A1) are membrane glycoproteins that can form homotrimers. This receptor was originally defined by its ability to mediate the accumulation of lipids in macrophages. Subsequent studies reveal that SR-A1 plays critical roles in innate immunity, cell apoptosis and proliferation. This review highlights recent advances in understanding the structure, receptor pathway and regulation of SR-A1. Although its role in atherosclerosis is disputable, recent discoveries suggest that SR-A1 function in anti-inflammatory responses by promoting an M2 macrophage phenotype in cardiovascular diseases. Therefore, SR-A1 may be a potential target for therapeutic intervention of cardiovascular diseases.
A1 类清道夫受体(SR-A1)是一种能够形成同三聚体的膜糖蛋白。该受体最初是因其介导巨噬细胞中脂质蓄积的能力而被定义的。随后的研究表明,SR-A1 在先天免疫、细胞凋亡和增殖中发挥着关键作用。本综述重点介绍了在理解 SR-A1 的结构、受体途径和调控方面的最新进展。尽管其在动脉粥样硬化中的作用存在争议,但最近的发现表明,SR-A1 通过促进心血管疾病中 M2 巨噬细胞表型而在抗炎反应中发挥作用。因此,SR-A1 可能是心血管疾病治疗干预的一个潜在靶点。