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Nat Rev Neurosci. 2013 Jun;14(6):401-16. doi: 10.1038/nrn3505. Epub 2013 May 15.
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Integrin αIIbβ3: from discovery to efficacious therapeutic target.整合素 αIIbβ3:从发现到有效的治疗靶点。
Circ Res. 2013 Apr 12;112(8):1189-200. doi: 10.1161/CIRCRESAHA.112.300570.
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Exploring mechanisms of FGF signalling through the lens of structural biology.通过结构生物学探索 FGF 信号通路的机制。
Nat Rev Mol Cell Biol. 2013 Mar;14(3):166-80. doi: 10.1038/nrm3528. Epub 2013 Feb 13.
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Eph receptors and their ligands: promising molecular biomarkers and therapeutic targets in prostate cancer.Eph受体及其配体:前列腺癌中有前景的分子生物标志物和治疗靶点。
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《2013/14药理学简明指南:催化受体》

The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors.

作者信息

Alexander Stephen P H, Benson Helen E, Faccenda Elena, Pawson Adam J, Sharman Joanna L, Spedding Michael, Peters John A, Harmar Anthony J

机构信息

School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

出版信息

Br J Pharmacol. 2013 Dec;170(8):1676-705. doi: 10.1111/bph.12449.

DOI:10.1111/bph.12449
PMID:24528241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3892291/
Abstract

The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full. Catalytic receptors are one of the seven major pharmacological targets into which the Guide is divided, with the others being G protein-coupled receptors, ligand-gated ion channels, ion channels, nuclear hormone receptors, transporters and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. A new landscape format has easy to use tables comparing related targets. It is a condensed version of material contemporary to late 2013, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in previous Guides to Receptors and Channels. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and the Guide to Receptors and Channels, providing a permanent, citable, point-in-time record that will survive database updates.

摘要

《2013/14药理学简明指南》简要概述了2000多种人类药物靶点的关键特性及其药理学,还提供了药物靶点及其配体的开放获取知识库链接(www.guidetopharmacology.org),该知识库能提供靶点和配体特性的更详细信息。完整内容可在http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full查询。催化受体是该指南划分的七个主要药理学靶点之一,其他靶点包括G蛋白偶联受体、配体门控离子通道、离子通道、核激素受体、转运体和酶。书中给出了命名指南以及关于现有最佳药理学工具的总结信息,还有关键参考文献和进一步阅读建议。新的版面格式有便于使用的表格,可比较相关靶点。它是2013年末当代资料的精简版,网站www.guidetopharmacology.org上有更详细的内容且不断更新,取代了之前的《受体与通道指南》中的数据。它是与NC-IUPHAR联合制作的,在适当之处提供人类药物靶点的官方IUPHAR分类和命名。它整合了之前在IUPHAR-DB以及《受体与通道指南》中分别整理和展示的信息,提供了一份永久性的、可引用的、特定时间点的记录,即使数据库更新也能留存。