Sajjadi Mahmoud, Gholamrezaei Ali, Daryani Nasser Ebrahimi
Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran,
Dig Dis Sci. 2015 Jun;60(6):1755-60. doi: 10.1007/s10620-014-3510-y. Epub 2015 Feb 5.
Adenosine deaminase activity is proposed as a marker of inflammation in some inflammatory conditions.
To investigate the association of serum adenosine deaminase activity and disease activity in Crohn's disease patients.
In a cross-sectional study, 30 consecutive known cases of Crohn's disease (15 with active disease and 15 in remission) referring to a university hospital in Tehran (Iran) and 15 age- and gender-matched healthy controls were studied. Disease activity was assessed using the Crohn's disease activity index (cutoff >150). Total serum adenosine deaminase activity, C-reactive protein, erythrocyte sedimentation rate, and fecal calprotectin were evaluated in patients. Serum adenosine deaminase activity was measured in controls.
Mean age of the patients was 36.8 ± 12.6 years, and 56.7 % were male. Serum adenosine deaminase activity in patients with active disease, patients in remission, and controls was 12.3 ± 5.9, 14.6 ± 6.2, and 11.9 ± 6.4 U/L, respectively (P = 0.458). Compared with patients in remission, those with active disease had higher erythrocyte sedimentation rate (40.4 ± 30.6 vs. 16.9 ± 16.0 mm/h, P = 0.014) and higher frequency of positive C-reactive protein (66.6 vs. 13.3 %, P = 0.004) and positive fecal calprotectin tests (86.6 vs. 33.3 %, P = 0.004). Serum adenosine deaminase activity was not correlated with erythrocyte sedimentation rate (r = 0.05, P = 0.761) and was not different between patients with positive and negative C-reactive protein (12.2 ± 5.4 vs. 14.2 ± 6.5 U/L, P = 0.393) and fecal calprotectin tests (11.7 ± 5.3 vs. 16.0 ± 6.5 U/L, P = 0.063).
In patients with Crohn's disease, serum adenosine deaminase activity is not associated with clinical disease activity or with other inflammation markers and cannot be suggested as an inflammation marker.
在某些炎症性疾病中，腺苷脱氨酶活性被认为是炎症的一个标志物。
研究克罗恩病患者血清腺苷脱氨酶活性与疾病活动度之间的关联。
在一项横断面研究中，对转诊至德黑兰（伊朗）一家大学医院的30例连续的已知克罗恩病病例（15例疾病活动期患者和15例缓解期患者）以及15例年龄和性别匹配的健康对照者进行了研究。使用克罗恩病活动指数（临界值>150）评估疾病活动度。对患者评估了血清总腺苷脱氨酶活性、C反应蛋白、红细胞沉降率和粪便钙卫蛋白。对对照者测定了血清腺苷脱氨酶活性。
患者的平均年龄为36.8±12.6岁，56.7%为男性。疾病活动期患者、缓解期患者和对照者的血清腺苷脱氨酶活性分别为12.3±5.9、14.6±6.2和11.9±6.4 U/L（P = 0.458）。与缓解期患者相比，疾病活动期患者的红细胞沉降率更高（40.4±30.6对16.9±16.0 mm/h，P = 0.014），C反应蛋白阳性频率更高（66.6%对13.3%，P = 0.004），粪便钙卫蛋白检测阳性频率更高（86.6%对33.3%，P = 0.004）。血清腺苷脱氨酶活性与红细胞沉降率无相关性（r = 0.05，P = 0.761），C反应蛋白阳性和阴性患者之间（12.2±5.4对14.2±6.5 U/L，P = 0.393）以及粪便钙卫蛋白检测阳性和阴性患者之间（11.7±5.3对16.0±6.5 U/L，P = 0.063）血清腺苷脱氨酶活性无差异。
在克罗恩病患者中，血清腺苷脱氨酶活性与临床疾病活动度或其他炎症标志物无关，不能被推荐作为炎症标志物。
