Shay Gemma, Lynch Conor C, Fingleton Barbara
Dept. of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Dept of Cancer Biology, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, TN 37232, USA.
Matrix Biol. 2015 May-Jul;44-46:200-6. doi: 10.1016/j.matbio.2015.01.019. Epub 2015 Jan 31.
Matrix metalloproteinases have long been associated with cancer. Clinical trials of small molecule inhibitors for this family of enzymes however, were spectacularly unsuccessful in a variety of tumor types. Here, we discuss some of the newer roles that have been uncovered for MMPs in cancer that would not have been targeted with those initial inhibitors or in the patient populations analyzed. We also consider novel ways of using cancer-associated MMP activity for clinical benefit.
基质金属蛋白酶长期以来一直与癌症相关。然而,针对这类酶的小分子抑制剂的临床试验在多种肿瘤类型中都极不成功。在此,我们讨论基质金属蛋白酶在癌症中发现的一些新作用,这些作用在最初的抑制剂中未被靶向,或者在分析的患者群体中未被关注。我们还考虑利用与癌症相关的基质金属蛋白酶活性来实现临床益处的新方法。