Jonasson A, Larsson B
Department of Obstetrics and Gynecology, Karolinska Institutet, Huddinge University Hospital, Sweden.
Int J Gynaecol Obstet. 1989 Apr;28(4):361-4. doi: 10.1016/0020-7292(89)90609-7.
In 14 legal first trimester abortions, vacuum aspiration was preceded by dilatation of the cervical canal by laminaria tent for 16-20 h. Biopsy specimens obtained from the cervix before insertion and before removal of the laminaria tent were analyzed for biochemical changes in cervical connective tissue. Pretreatment with laminaria tents resulted in a decrease of the total collagen concentration and of the collagenolytic activity, though the differences were without statistical significance. Both these findings and those concerning the subfractions of the hydroxyproline concentration suggest that pretreatment with laminaria induces a certain degree of softening of the cervix, similar to that reported after intracervical application of PGE2 gel.
在14例法律允许的孕早期人工流产中，在进行真空吸引术之前，先用海藻棒扩张宫颈管16 - 20小时。在插入海藻棒之前和取出海藻棒之前从宫颈获取活检标本，分析宫颈结缔组织的生化变化。海藻棒预处理导致总胶原蛋白浓度和胶原olytic活性降低，尽管差异无统计学意义。这些发现以及关于羟脯氨酸浓度亚组分的发现均表明，海藻棒预处理可诱导宫颈一定程度的软化，类似于宫颈内应用前列腺素E2凝胶后所报道的情况。
