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利用线粒体和核糖体DNA多态性对荚膜组织胞浆菌的临床分离株和土壤分离株进行分类。

Use of mitochondrial and ribosomal DNA polymorphisms to classify clinical and soil isolates of Histoplasma capsulatum.

作者信息

Spitzer E D, Lasker B A, Travis S J, Kobayashi G S, Medoff G

机构信息

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

出版信息

Infect Immun. 1989 May;57(5):1409-12. doi: 10.1128/iai.57.5.1409-1412.1989.

DOI:10.1128/iai.57.5.1409-1412.1989
PMID:2565290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC313291/
Abstract

We have developed an improved scheme for the classification of environmental and clinical isolates of Histoplasma capsulatum that is based on analysis of mitochondrial DNA (mtDNA) and ribosomal DNA (rDNA). Strains were initially divided into mtDNA groups according to restriction digests of whole-cell DNA and Southern hybridization with cloned mtDNA probes. Strains within a mtDNA class could be further grouped by polymorphisms in rDNA. The majority of soil and clinical isolates from the United States had identical mtDNA patterns; however, rDNA polymorphisms were common in both types of isolates. The combination of mtDNA and rDNA typing described in this report will be useful in resolving questions concerning the epidemiology of H. capsulatum infections.

摘要

我们基于对线粒体DNA（mtDNA）和核糖体DNA（rDNA）的分析，开发了一种改进的荚膜组织胞浆菌环境和临床分离株分类方案。菌株最初根据全细胞DNA的限制性酶切和与克隆的mtDNA探针的Southern杂交分为mtDNA组。mtDNA类中的菌株可根据rDNA的多态性进一步分组。来自美国的大多数土壤和临床分离株具有相同的mtDNA模式；然而，rDNA多态性在这两种类型的分离株中都很常见。本报告中描述的mtDNA和rDNA分型组合将有助于解决有关荚膜组织胞浆菌感染流行病学的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/313291/bcd498c5bf39/iai00065-0071-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/313291/598780e493e1/iai00065-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/313291/e5892281815b/iai00065-0070-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/313291/c06bf5d40dc0/iai00065-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/313291/bcd498c5bf39/iai00065-0071-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/313291/598780e493e1/iai00065-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/313291/e5892281815b/iai00065-0070-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/313291/c06bf5d40dc0/iai00065-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6581/313291/bcd498c5bf39/iai00065-0071-b.jpg

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