Chakir J, Rouabhia M, Deschaux P
Laboratory of Animal Physiology, General and Comparative Immunology, University of Limoges, France.
Immunopharmacology. 1989 Jan-Feb;17(1):31-5. doi: 10.1016/0162-3109(89)90005-2.
The present study investigates the in vitro effect of methionine-enkephalin (Met-Enk) on Thy1-2 antigen density and the interaction between this opioid peptide and a thymic hormone (thymosin fraction V (TFV]. In vitro, it was found that Met-Enk at various concentrations (28.10(-11), 28.10(-10), 28.10(-9) and 28.10(-8) M) had an increased positive effect on the Thy1-2 antigen density of Balb/C mouse thymocytes. This action was observed at all concentrations of Met-Enk. The addition of TFV to Met-Enk thymocyte cultures showed an additive effect of these two hormones. The physiological significance of these observations is that they indicate an interaction between immune and endocrine system functions.
本研究调查了甲硫氨酸脑啡肽（Met-Enk）对Thy1-2抗原密度的体外作用，以及这种阿片肽与一种胸腺激素（胸腺素组分V，TFV）之间的相互作用。在体外，发现不同浓度（28×10⁻¹¹、28×10⁻¹⁰、28×10⁻⁹和28×10⁻⁸ M）的Met-Enk对Balb/C小鼠胸腺细胞的Thy1-2抗原密度具有增强的正向作用。在所有浓度的Met-Enk下均观察到这种作用。向Met-Enk胸腺细胞培养物中添加TFV显示这两种激素具有相加作用。这些观察结果的生理学意义在于它们表明了免疫和内分泌系统功能之间的相互作用。
