Ligands specific to peripheral benzodiazepine receptors for treatment of porphyrias.
作者信息
Katz Y, Weizman A, Gavish M
机构信息
Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel.
出版信息
Lancet. 1989 Apr 29;1(8644):932-3. doi: 10.1016/s0140-6736(89)92510-5.
PMID:2565422
Abstract
Accumulating data indicate that porphyrins are physiologically endogenous ligands to mitochondrial peripheral benzodiazepine receptors. An isoquinoline carboxamide derivative that likewise binds to peripheral benzodiazepine receptors could prove therapeutically useful in porphyrias by displacing porphyrins from these receptors in mitochondria.
摘要
Zotero 插件