Bergstein N A
Ciba Found Symp. 1978(63):255-64. doi: 10.1002/9780470720462.ch12.
A relationship between maternal diabetes and fetal malformations has been recognized for a long time, but there has been considerable difference of opinion about the size of the risk. Several defects of the pelvis and lower limbs appear to be relatively common in offspring of diabetic mothers. In experimental studies a dose relationship has been shown between some drugs (insulin-Trypan blue) and lower limb malformations. Three patients are discribed with congenital malformations with diabetes or prediabetes during pregnancy. Is the caudal regression syndrome a part of a larger syndrome caused by a disturbance of glucose homeostasis?
母体糖尿病与胎儿畸形之间的关系早已为人所知，但对于风险大小存在相当大的意见分歧。糖尿病母亲的后代中，骨盆和下肢的一些缺陷似乎相对常见。在实验研究中，已显示某些药物（胰岛素-台盼蓝）与下肢畸形之间存在剂量关系。本文描述了三名在孕期患有糖尿病或糖尿病前期并伴有先天性畸形的患者。尾椎退化综合征是否是由葡萄糖稳态紊乱引起的更大综合征的一部分？
