Howland Robert H
J Psychosoc Nurs Ment Health Serv. 2015 Feb;53(2):23-5. doi: 10.3928/02793695-20150122-01.
A potential adverse effect of some psychiatric medications is an abnormally prolonged corrected QT (QTc) interval and an increased risk of developing Torsade de Pointes (TdP), which is associated with sudden death. Because antidepressant and antipsychotic drug use is increasing and rates of sudden cardiac death are decreasing, the proportion of sudden cardiac death cases that may be attributed to these drugs is likely to be exceedingly small compared to other risk factors. A comprehensive review of the published literature has concluded that there is little evidence that psychotropic drug-associated QTc interval prolongation by itself is sufficient to predict TdP.
一些精神科药物的潜在不良反应是校正QT（QTc）间期异常延长以及发生尖端扭转型室速（TdP）的风险增加，而TdP与猝死相关。由于抗抑郁药和抗精神病药的使用正在增加，而心源性猝死的发生率正在下降，与其他风险因素相比，可能归因于这些药物的心源性猝死病例所占比例可能极小。对已发表文献的全面综述得出结论，几乎没有证据表明精神药物相关的QTc间期延长本身足以预测TdP。
