成纤维细胞生长因子23与骨矿化
Fibroblast growth factor 23 and bone mineralisation.
作者信息
Guo Yu-Chen, Yuan Quan
机构信息
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
出版信息
Int J Oral Sci. 2015 Mar 23;7(1):8-13. doi: 10.1038/ijos.2015.1.
Abstract
Fibroblast growth factor 23 (FGF23) is a hormone that is mainly secreted by osteocytes and osteoblasts in bone. The critical role of FGF23 in mineral ion homeostasis was first identified in human genetic and acquired rachitic diseases and has been further characterised in animal models. Recent studies have revealed that the levels of FGF23 increase significantly at the very early stages of chronic kidney disease (CKD) and may play a critical role in mineral ion disorders and bone metabolism in these patients. Our recent publications have also shown that FGF23 and its cofactor, Klotho, may play an independent role in directly regulating bone mineralisation instead of producing a systematic effect. In this review, we will discuss the new role of FGF23 in bone mineralisation and the pathophysiology of CKD-related bone disorders.
摘要
成纤维细胞生长因子23（FGF23）是一种主要由骨中的骨细胞和成骨细胞分泌的激素。FGF23在矿物质离子稳态中的关键作用最初是在人类遗传性和获得性佝偻病疾病中发现的，并在动物模型中得到了进一步的表征。最近的研究表明，在慢性肾脏病（CKD）的极早期阶段，FGF23水平会显著升高，并且可能在这些患者的矿物质离子紊乱和骨代谢中起关键作用。我们最近的出版物还表明，FGF23及其辅助因子α-klotho可能在直接调节骨矿化方面发挥独立作用，而不是产生系统性影响。在这篇综述中，我们将讨论FGF23在骨矿化中的新作用以及CKD相关骨疾病的病理生理学。
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本文引用的文献
1
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Bone Res. 2013 Jun 28;1(2):120-32. doi: 10.4248/BR201302002. eCollection 2013 Jun.
2
Increased osteopontin contributes to inhibition of bone mineralization in FGF23-deficient mice.骨桥蛋白增加有助于抑制FGF23基因敲除小鼠的骨矿化。
J Bone Miner Res. 2014 Mar;29(3):693-704. doi: 10.1002/jbmr.2079.
3
Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology.成纤维细胞生长因子信号在生理和病理中的分子机制。
Cold Spring Harb Perspect Biol. 2013 Jun 1;5(6):a015958. doi: 10.1101/cshperspect.a015958.
4
Fibroblast growth factor 23, Klotho, and disordered mineral metabolism in chronic kidney disease: unraveling the intricate tapestry of events and implications for therapy.成纤维细胞生长因子 23、Klotho 和慢性肾脏病中的矿物质代谢紊乱：揭示事件的复杂关系及其对治疗的影响。
J Ren Nutr. 2013 May;23(3):250-4. doi: 10.1053/j.jrn.2013.01.024.
5
A comparative transcriptome analysis identifying FGF23 regulated genes in the kidney of a mouse CKD model.一项比较转录组分析鉴定了在小鼠 CKD 模型肾脏中受 FGF23 调控的基因。
PLoS One. 2012;7(9):e44161. doi: 10.1371/journal.pone.0044161. Epub 2012 Sep 6.
6
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J Clin Invest. 2012 Jul;122(7):2543-53. doi: 10.1172/JCI61405. Epub 2012 Jun 25.
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8
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J Cell Biochem. 2012 Jul;113(7):2432-41. doi: 10.1002/jcb.24115.
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