Griesmaier E, Burger C, Ralser E, Neubauer V, Kiechl-Kohlendorfer U
Department of Pediatrics II, Neonatology, Innsbruck Medical University, Innsbruck, Austria.
Acta Paediatr. 2015 Jul;104(7):e283-8. doi: 10.1111/apa.12967. Epub 2015 Mar 27.
Being born small for gestational age (SGA) seems to be a relevant risk factor for long-term neurologic deficits. We compared the differences between amplitude-integrated electroencephalography (aEEG) signals in very preterm infants born small for gestational age (SGA) and those in age-matched infants born appropriate size for gestational age (AGA).
We performed serial aEEG recording on 305 infants: 255 (83.6%) were AGA, and 50 (16.3%) were SGA.
The number of bursts per hour decreased over time in both groups, but was higher in the SGA group at every time point. On day one, it was significantly higher in the SGA group (17.4) than in the AGA group (10.1) (p = 0.016). The total Burdjalov score increased with post-natal age and tended to be lower in SGA infants, but did not reach statistical significance at any time point. The percentage of continuous background patterns increased with post-natal age in both groups, with no significant difference between the groups.
Very preterm infants born SGA showed normal maturation of aEEG signals during post-natal life, but they also showed mild delays in electrocortical activity compared to age-matched AGA infants. The predictive value of these findings on neurodevelopmental outcome needs to be further evaluated.
小于胎龄儿（SGA）出生似乎是长期神经功能缺损的一个相关危险因素。我们比较了小于胎龄的极早产儿与年龄匹配的适于胎龄儿（AGA）的振幅整合脑电图（aEEG）信号差异。
我们对305例婴儿进行了系列aEEG记录：255例（83.6%）为AGA，50例（16.3%）为SGA。
两组每小时的爆发次数均随时间减少，但SGA组在每个时间点均更高。在出生第一天，SGA组（17.4次）显著高于AGA组（10.1次）（p = 0.016）。Burdjalov总分随出生后年龄增加，SGA婴儿往往较低，但在任何时间点均未达到统计学显著性。两组连续背景模式的百分比均随出生后年龄增加，两组间无显著差异。
小于胎龄的极早产儿在出生后aEEG信号成熟正常，但与年龄匹配的AGA婴儿相比，其电皮质活动也有轻度延迟。这些发现对神经发育结局的预测价值需要进一步评估。
