Leng Sean X, Margolick Joseph B
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, John R. Burton Pavilion, 5505 Hopkins Bayview Circle, Baltimore, MD, 21224, USA,
Curr HIV/AIDS Rep. 2015 Mar;12(1):25-32. doi: 10.1007/s11904-014-0247-3.
Frailty is a clinical syndrome initially characterized in geriatric populations with a hallmark of age-related declines in physiologic reserve and function and increased vulnerability to adverse health outcomes. Recently, frailty has increasingly been recognized as a common and important HIV-associated non-AIDS (HANA) condition. This article provides an overview of our current understanding of frailty and its phenotypic characteristics and evidence that they are related to aging and to chronic inflammation that is associated with aging and also with long-term treated HIV infection. The etiology of this chronic inflammation is unknown but we discuss evidence linking it to persistent infection with cytomegalovirus in both geriatric populations and people living with HIV infection.
衰弱是一种临床综合征，最初在老年人群中被发现，其特征是生理储备和功能出现与年龄相关的下降，且更容易出现不良健康后果。最近，衰弱越来越被认为是一种常见且重要的与HIV相关的非艾滋病（HANA）状况。本文概述了我们目前对衰弱及其表型特征的理解，以及它们与衰老、与衰老相关的慢性炎症以及长期接受治疗的HIV感染之间关系的证据。这种慢性炎症的病因尚不清楚，但我们讨论了在老年人群和HIV感染者中将其与巨细胞病毒持续感染联系起来的证据。
