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甜蜜的结局带来苦涩：肺癌细胞表面蛋白糖基化介导转移定植。

Sweets for a bitter end: lung cancer cell-surface protein glycosylation mediates metastatic colonization.

作者信息

Arnal-Estapé Anna, Nguyen Don X

机构信息

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut. Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut.

出版信息

Cancer Discov. 2015 Feb;5(2):109-11. doi: 10.1158/2159-8290.CD-15-0013.

DOI:10.1158/2159-8290.CD-15-0013
PMID:25656895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4340588/
Abstract

Glycosylation is one of the most predominant forms of cell-surface protein modifications, yet its deregulation in cancer and contribution to tumor microenvironment interactions remain poorly understood. In this issue of Cancer Discovery, Reticker-Flynn and Bhatia characterize an enzymatic switch in lung cancer cells that triggers aberrant surface protein glycosylation patterns, adhesion to lectins on the surface of inflammatory cells, and subsequent metastatic colonization of the liver.

摘要

糖基化是细胞表面蛋白修饰最主要的形式之一，然而其在癌症中的失调以及对肿瘤微环境相互作用的影响仍知之甚少。在本期《癌症发现》杂志中，雷蒂克-弗林和巴蒂亚描述了肺癌细胞中的一种酶促开关，该开关触发异常的表面蛋白糖基化模式、与炎症细胞表面凝集素的粘附以及随后肝脏的转移定植。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d313/4340588/f7a2ad661be9/nihms-655428-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d313/4340588/f7a2ad661be9/nihms-655428-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d313/4340588/f7a2ad661be9/nihms-655428-f0001.jpg

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Cancer Discov. 2015 Feb;5(2):168-81. doi: 10.1158/2159-8290.CD-13-0760. Epub 2014 Nov 24.
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Differentially expressed glycosylated patterns of α-1-antitrypsin as serum biomarkers for the diagnosis of lung cancer.α-1-抗胰蛋白酶的差异表达糖基化模式作为肺癌诊断的血清生物标志物
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Sialic acids sweeten a tumor's life.
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Glycosylation Changes in Brain Cancer.脑癌中的糖基化改变。
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