Sato Yumi, Tanaka Kei, Kobayashi Yoichi, Shibuya Hiromi, Nishigaya Yoshiko, Momomura Mai, Matsumoto Hironori, Iwashita Mitsutoshi
Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
J Obstet Gynaecol Res. 2015 Jul;41(7):1145-8. doi: 10.1111/jog.12668. Epub 2015 Feb 6.
Brain metastasis from uterine cervical cancer is rare, with an incidence of 0.5%, and usually occurs late in the course of the disease. We report a case of uterine cervical cancer with brain metastasis as the initial site of presentation. A 50-year-old woman with headache, vertigo, amnesia and loss of appetite was admitted for persistent vomiting. Contrast enhanced computed tomography showed a solitary right frontal cerebral lesion with ring enhancement and uterine cervical tumor. She was diagnosed with uterine cervical squamous cell carcinoma with parametrium invasion and no other distant affected organs were detected. The cerebral lesion was surgically removed and pathologically proved to be metastasis of uterine cervical squamous cell carcinoma. The patient underwent concurrent chemoradiotherapy, followed by cerebral radiation therapy, but multiple metastases to the liver and lung developed and the patient died 7 months after diagnosis of brain metastasis.
子宫颈癌脑转移罕见，发生率为0.5%，通常发生于疾病晚期。我们报告1例以脑转移为首发表现部位的子宫颈癌病例。一名50岁女性因持续性呕吐入院，伴有头痛、眩晕、失忆及食欲减退。增强计算机断层扫描显示右侧额叶有一个孤立的脑内病灶，呈环形强化，同时发现子宫颈肿瘤。她被诊断为子宫颈鳞状细胞癌伴宫旁浸润，未检测到其他远处受累器官。脑内病灶经手术切除，病理证实为子宫颈鳞状细胞癌转移。患者接受同步放化疗，随后进行脑部放射治疗，但出现了肝和肺的多发转移，在诊断脑转移后7个月死亡。
