Nelson Lindsay D, Strickland Casey, Krueger Robert F, Arbisi Paul A, Patrick Christopher J
Medical College of Wisconsin, Milwaukee, WI, USA
Florida State University, Tallahassee, FL, USA.
Assessment. 2016 Feb;23(1):75-85. doi: 10.1177/1073191115570110. Epub 2015 Feb 5.
The National Institute of Mental Health Research Domain Criteria initiative (Insel et al., 2010) calls for a focus on biologically meaningful dimensional constructs in the study of clinical problems. Examples are needed of how Research Domain Criteria constructs can be linked to clinical problems. We examined how two such constructs, threat sensitivity (THT+) and weak inhibitory control (INH-), operationalized using scale measures of fear/fearlessness and inhibition/disinhibition dimensions from established structural models, predicted symptoms of multiple Diagnostic and Statistical Manual of Mental Disorders (4th edition) clinical disorders in 471 community adults. Robust relationships with internalizing disorder symptoms were evident for both trait variables, with THT+ more predictive of fear disorder symptoms and INH- more predictive of distress disorder symptoms. For substance-related problems, prediction was evident only for INH-. Additionally, interactive effects of THT+ and INH- were found for distress disorders, and to a lesser extent, fear disorders. Given their well-established physiological correlates, these dispositional variables represent prime targets for combined psychometric-neurophysiological assessment of broad liabilities to multiple forms of psychopathology.
美国国立精神卫生研究所研究领域标准计划（英塞尔等人，2010年）呼吁在临床问题研究中关注具有生物学意义的维度结构。需要举例说明研究领域标准结构如何与临床问题相联系。我们研究了两个这样的结构，即威胁敏感性（THT+）和弱抑制控制（INH-），它们是使用既定结构模型中恐惧/无畏和抑制/去抑制维度的量表测量来操作化的，如何预测471名社区成年人中多种《精神障碍诊断与统计手册》（第4版）临床疾病的症状。这两个特质变量与内化障碍症状均存在显著关系，其中THT+对恐惧障碍症状的预测性更强，而INH-对痛苦障碍症状的预测性更强。对于与物质相关的问题，仅INH-有预测作用。此外，发现THT+和INH-对痛苦障碍存在交互作用，对恐惧障碍的交互作用程度较小。鉴于它们已确立的生理相关性，这些倾向性变量是对多种形式精神病理学广泛易感性进行心理测量-神经生理学联合评估的主要目标。
