长期服用抗抑郁药和抗精神病药对中枢神经系统受体的影响。
Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system.
作者信息
Baker G B, Greenshaw A J
机构信息
Department of Psychiatry, University of Alberta, Edmonton, Canada.
出版信息
Cell Mol Neurobiol. 1989 Mar;9(1):1-44. doi: 10.1007/BF00711441.
Abstract
- A review of the effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system is presented. 2. The effects of antidepressants on adenylate cyclase activity and on receptor binding in brain tissue are discussed. Effects on a variety of receptor types are considered. 3. The utilization of electrophysiological, behavioral, and neurochemical studies to assess receptor function after chronic antidepressant administration is discussed, as is the use of peripheral receptor estimations in clinical studies. 4. Animal studies on the actions of chronic administration of neuroleptics on pre- and postsynaptic dopamine receptors are reviewed. Effects of these drugs on dopamine receptors in humans are considered from the following perspectives: postmortem and in vivo binding studies in schizophrenia, tardive dyskinesia, and central versus peripheral receptor estimation.
摘要
- 本文综述了长期服用抗抑郁药和抗精神病药对中枢神经系统受体的影响。2. 讨论了抗抑郁药对脑组织中腺苷酸环化酶活性和受体结合的影响。考虑了对多种受体类型的影响。3. 讨论了利用电生理、行为和神经化学研究来评估长期服用抗抑郁药后的受体功能，以及在临床研究中使用外周受体评估的情况。4. 综述了关于长期服用抗精神病药对突触前和突触后多巴胺受体作用的动物研究。从以下角度考虑了这些药物对人类多巴胺受体的影响：精神分裂症的死后和体内结合研究、迟发性运动障碍以及中枢与外周受体评估。
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