Khan Mahboob, Ortega Luis M, Bagwan Nasreen, Nayer Ali
Division of nephrology and Hypertension, Allegheny General Hospital, Temple University School of Medicine, Pittsburgh, PA, USA.
Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, USA.
J Nephropathol. 2015 Jan;4(1):29-31. doi: 10.12860/jnp.2015.06. Epub 2015 Jan 1.
Fluoroquinolones are known to cause acute renal failure due to interstitial nephritis.
Here we present an elderly woman who developed oliguric acute kidney injury (AKI) after receiving oral and intravenous ciprofloxacin in a 48-hour period. Recently, several case reports have been published in the literature regarding the presence of crystals in the urine sediment of patients treated with ciprofloxacin for different types of systemic infections. Ciprofloxacin crystals precipitate in alkaline urine and provoke renal failure through intra-tubular precipitation.
Conservative measures including intravenous hydration and avoidance of alkalinization of the urine can reverse this condition if applied in time.
已知氟喹诺酮类药物可因间质性肾炎导致急性肾衰竭。
在此我们报告一名老年女性，在48小时内接受口服及静脉注射环丙沙星后发生少尿型急性肾损伤（AKI）。最近，文献中发表了几例关于不同类型全身感染患者接受环丙沙星治疗后尿沉渣中出现晶体的病例报告。环丙沙星晶体在碱性尿液中沉淀，并通过肾小管内沉淀引发肾衰竭。
如果及时采取包括静脉补液和避免尿液碱化在内的保守措施，可逆转这种情况。
