可卡因诱发的急性间质性肾炎：一例病例报告及文献综述
Cocaine-induced acute interstitial nephritis: A case report and review of the literature.
作者信息
Alfaro Rodrigo, Vasavada Nina, Paueksakon Paisit, Hernandez German T, Aronoff George R
机构信息
Division of Nephrology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
出版信息
J Nephropathol. 2013 Jul;2(3):204-9. doi: 10.12860/JNP.2013.33. Epub 2013 Jul 1.
BACKGROUND
Acute tubular necrosis and pigment induced kidney injury are well described consequences of cocaine abuse. However, acute interstitial nephritis associated with cocaine use has been previously reported in only three patients.
CASE PRESENTATION
We present the case of a 49-year-old man who developed acute kidney injury from biopsy-proven interstitial nephritis after nasal insufflation of cocaine. Unlike prior reports, our patient remained non-oliguric and did not require renal replacement therapy.
CONCLUSIONS
Interstitial nephritis should be considered as a potential cause of acute kidney injury associated with cocaine use. The approach to management of cocaine associated acute kidney injury (AKI) may be different in patients with interstitial nephritis than for those with tubular necrosis or pigment induced renal injury.
背景
急性肾小管坏死和色素诱导的肾损伤是可卡因滥用的常见后果。然而，此前仅有3例报告了与使用可卡因相关的急性间质性肾炎。
病例报告
我们报告了一名49岁男性的病例，该患者在经鼻吸入可卡因后，经活检证实为间质性肾炎并发展为急性肾损伤。与先前的报告不同，我们的患者仍无少尿情况，且不需要肾脏替代治疗。
结论
间质性肾炎应被视为与使用可卡因相关的急性肾损伤的潜在原因。对于间质性肾炎患者，可卡因相关急性肾损伤（AKI）的管理方法可能与肾小管坏死或色素诱导的肾损伤患者不同。
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