Mezni Imen, Galichon Pierre, Bacha Mohamed Mongi, Sfar Imen, Hertig Alexandre, Goucha Rim, Xu-Dubois Yi-Chun, Abderrahim Ezzedine, Gorgi Yousr, Rondeau Eric, Abdallah Taieb Ben
Inserm UMR_S 1155, des maladies rénales rares aux maladies fréquentes, remodelage et réparation, hôpital Tenon, bâtiment recherche, 4, rue la Chine, 75020 Paris, France - laboratoire de recherche d'immunologie de la transplantation rénale et d'immunopathologie (LR03SP01), EPS Charles Nicolle, Tunis, Tunisie.
Inserm UMR_S 1155, des maladies rénales rares aux maladies fréquentes, remodelage et réparation, hôpital Tenon, bâtiment recherche, 4, rue la Chine, 75020 Paris, France - urgences néphrologiques et transplantation rénale, APHP, hôpital Tenon, Paris, France.
Med Sci (Paris). 2015 Jan;31(1):68-74. doi: 10.1051/medsci/20153101015. Epub 2015 Feb 6.
Epithelial-mesenchymal transition (EMT) is a process by which differentiated epithelial cells undergo a phenotypic conversion and acquire a mesenchymal phenotype, including elongated morphology, enhanced migratory and invasion capacity, and greatly increased production of extracellular matrix (ECM) components. This phenomenon plays a pivotal role in embryonic development, wound healing and tissue regeneration. It has also been involved in organ fibrosis. Some studies suggest that following injury, renal tubular epithelial cells undergo reprograming in mesenchymal cells, and thus constitute an important source of de novo myofibroblasts invading the renal interstitium and contributing to fibrosis. However, an increasing number of studies raise doubts about the existence of this process in vivo. The role of EMT in the development of renal fibrosis remains a matter of intense debate and may depend on the model studied. In this review, we describe the role of EMT in the development of fibrosis of renal graft, and then we propose approaches for detecting and treating renal fibrogenesis by targeting TEM.
上皮-间质转化（EMT）是一个分化的上皮细胞经历表型转换并获得间质表型的过程，包括形态拉长、迁移和侵袭能力增强以及细胞外基质（ECM）成分的产生大幅增加。这种现象在胚胎发育、伤口愈合和组织再生中起关键作用。它也与器官纤维化有关。一些研究表明，损伤后肾小管上皮细胞在间充质细胞中发生重编程，从而构成侵入肾间质并导致纤维化的新生肌成纤维细胞的重要来源。然而，越来越多的研究对该过程在体内的存在提出质疑。EMT在肾纤维化发展中的作用仍然是一个激烈争论的问题，可能取决于所研究的模型。在本综述中，我们描述了EMT在肾移植纤维化发展中的作用，然后我们提出了通过靶向EMT检测和治疗肾纤维化的方法。
