Terhaag B, Gramatté T, Richter K, Voss J, Feller K
Institute of Clinical Pharmacology, Medical Academy Carl Gustav Carus, Dresden, GDR.
Int J Clin Pharmacol Ther Toxicol. 1989 Apr;27(4):170-2.
The biliary elimination of the beta-1-receptor blocking agent talinolol was investigated after intravenous administration of 30 mg in 6 patients with a T-tube drain after cholecystectomy. Serum concentration decreased in a biexponential manner with a median terminal half-life time of 4.4 h (range: 3.0-6.2 h). In some patients a second peak of the serum level was found. Concentration-time curves in bile paralleled serum profiles. The bile:serum concentration ratio (b:s-ratio) ranged from 24 to 98. The biliary clearance amounted to 43 ml/h.kg (range: 13-212 ml/h.kg). The median of the amount of talinolol eliminated by bile was 2.8 mg (range: 1.1-7.4 mg). It is concluded that talinolol undergoes an enterohepatic circulation. However, the amount eliminated cannot provide a sufficient explanation for the second peak, observed in some patients.
在6例胆囊切除术后留置T形管引流的患者静脉注射30 mgβ1受体阻滞剂他林洛尔后，研究了其经胆汁的排泄情况。血清浓度呈双指数下降，中位终末半衰期为4.4小时（范围：3.0 - 6.2小时）。部分患者血清水平出现第二个峰值。胆汁中的浓度 - 时间曲线与血清曲线平行。胆汁与血清浓度比（b:s比）范围为24至98。胆汁清除率为43 ml/h·kg（范围：13 - 212 ml/h·kg）。经胆汁排泄的他林洛尔量的中位数为2.8 mg（范围：1.1 - 7.4 mg）。结论是他林洛尔存在肝肠循环。然而，排泄量不足以充分解释部分患者中观察到的第二个峰值。
