Chistiakov Dimitry A, Bobryshev Yuri V, Orekhov Alexander N
Research Center for Children's Health, 119991 Moscow, Russia; The Mount Sinai Community Clinical Oncology Program, Mount Sinai Comprehensive Cancer Center, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow 125315, Russia; Faculty of Medicine, School of Medical Sciences, University of New South Wales, Kensington, Sydney, NSW 2052, Australia; School of Medicine, University of Western Sydney, Campbelltown, NSW 2560, Australia.
Mol Immunol. 2015 May;65(1):133-8. doi: 10.1016/j.molimm.2015.01.013. Epub 2015 Feb 3.
The importance of immune inflammation in the development and progression of atherosclerotic lesions is well recognized. Accumulated evidence shows striking features of heterogeneity of regulatory T cells (Tregs) and the importance of the IL-12 cytokine family in regulation of Tregs in atherogenesis. The present review briefly summarized the current knowledge about the impact of the IL-12 cytokine family in regulation of immune processes in atherogenesis.
免疫炎症在动脉粥样硬化病变发生和发展中的重要性已得到充分认识。越来越多的证据表明调节性T细胞（Tregs）具有显著的异质性特征，以及白细胞介素-12（IL-12）细胞因子家族在动脉粥样硬化发生过程中调节Tregs的重要性。本综述简要总结了目前关于IL-12细胞因子家族对动脉粥样硬化发生过程中免疫过程调节影响的相关知识。
Zotero 插件