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应对环境应激的心脏病理生理学:当前综述

Cardiac pathophysiology in response to environmental stress: a current review.

作者信息

Tanwar Vineeta, Katapadi Aashish, Adelstein Jeremy M, Grimmer Jacob A, Wold Loren E

机构信息

Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.

College of Nursing, The Ohio State University, Columbus, OH.

出版信息

Curr Opin Physiol. 2018 Feb;1:198-205. doi: 10.1016/j.cophys.2017.11.005. Epub 2017 Dec 13.

Abstract

PURPOSE

Environmental stressors are disturbing our ecosystem at an accelerating rate. An increasingly relevant stressor are air pollutants, whose levels are increasing worldwide with threats to human health. These air pollutants are associated with increased mortality and morbidity from cardiovascular diseases. In this review we discuss environmental stressors focusing mainly on the various types of air pollutants, their short-term and long-term cardiovascular effects, and providing the epidemiological evidence associated with adverse cardiovascular outcomes. Direct and indirect pathophysiological mechanisms are also linked with cardiovascular complications such as thrombosis, fibrinolysis, hypertension, ischemic heart diseases and arrhythmias.

RESULTS

Evidence to date suggests that humans are constantly being exposed to unhealthy levels of environmental toxicants with the potential of serious health conditions. Environmental stressors adversely affect the cardiovascular system and pose an increased risk for cardiovascular diseases for those who reside in highly polluted areas.

CONCLUSION

People with existing risk factors and those with established cardiovascular disease have increased susceptibility to environmental stressors. The literature reviewed in this article thus support public health policies aimed at reducing pollutant exposure to benefit public health.

摘要

目的

环境应激源正以加速的速度扰乱我们的生态系统。空气污染物是一个日益相关的应激源,其在全球范围内的水平不断上升,对人类健康构成威胁。这些空气污染物与心血管疾病死亡率和发病率的增加有关。在本综述中,我们讨论环境应激源,主要关注各类空气污染物、它们对心血管的短期和长期影响,并提供与不良心血管结局相关的流行病学证据。直接和间接的病理生理机制也与心血管并发症如血栓形成、纤维蛋白溶解、高血压、缺血性心脏病和心律失常有关。

结果

迄今为止的证据表明,人类不断暴露于不健康水平的环境毒物中,有可能引发严重的健康问题。环境应激源对心血管系统产生不利影响,对于居住在高污染地区的人来说,患心血管疾病的风险增加。

结论

已有危险因素的人和已患心血管疾病的人对环境应激源的易感性增加。因此,本文所综述的文献支持旨在减少污染物暴露以促进公众健康的公共卫生政策。

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