Department of Microbiology, Faculty of Biomedical and Psychological Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Nat Rev Microbiol. 2015 Mar;13(3):160-72. doi: 10.1038/nrmicro3402. Epub 2015 Feb 9.
Post-translational modifications play crucial parts in regulating protein function and thereby control several fundamental aspects of eukaryotic biology, including cell signalling, protein trafficking, epigenetic control of gene expression, cell-cell interactions, and cell proliferation and differentiation. In this Review, we discuss protein modifications that have been shown to have a key role in malaria parasite biology and pathogenesis. We focus on phosphorylation, acetylation, methylation and lipidation. We provide an overview of the biological significance of these modifications and discuss prospects and progress in antimalarial drug discovery based on the inhibition of the enzymes that mediate these modifications.
翻译后修饰在调节蛋白质功能中起着关键作用，从而控制真核生物生物学的几个基本方面，包括细胞信号传导、蛋白质运输、基因表达的表观遗传控制、细胞间相互作用以及细胞增殖和分化。在本综述中，我们讨论了已被证明在疟原虫生物学和发病机制中起关键作用的蛋白质修饰。我们重点关注磷酸化、乙酰化、甲基化和脂化。我们概述了这些修饰的生物学意义，并讨论了基于抑制介导这些修饰的酶的抗疟药物发现的前景和进展。
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