Jørgensen B, Tønnesen K H, Bülow J, Nielsen J D, Jørgensen M, Holstein P, Andersen E
Department of Clinical Physiology/Nuclear Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
Lancet. 1989 May 20;1(8647):1106-8. doi: 10.1016/s0140-6736(89)92385-4.
To establish whether re-occlusion of the femoral artery could be prevented, in 6 consecutive patients undergoing percutaneous transluminal angioplasty (PTA) for superficial femoral artery occlusion the recanalised segment was isolated, with a 7-French double-balloon catheter. 5 mg recombined human tissue-type plasminogen activator (rt-PA) and 1000 IU heparin were then infused into the enclosed space for 30 minutes, followed by intravenous heparin for 24 hours. At 10 and 30 days all 6 patients had evidence of recanalisation and remission of symptoms. Mean ankle-arm pressure index improved by 72% at 24 hours, by 118% at 10 days, and by 103% at 30 days after the procedure. No patients had major complications. Treatment of superficial femoral artery occlusions by PTA with rt-PA and intravenous heparin seems to prevent rethrombosis.
为确定股动脉再闭塞能否得到预防，对6例因股浅动脉闭塞而接受经皮腔内血管成形术（PTA）的连续患者，使用7F双球囊导管隔离再通段。然后将5mg重组人组织型纤溶酶原激活剂（rt-PA）和1000IU肝素注入封闭空间30分钟，随后静脉注射肝素24小时。在10天和30天时，所有6例患者均有再通及症状缓解的证据。术后24小时平均踝臂压力指数改善72%，10天时改善118%，30天时改善103%。无患者出现严重并发症。PTA联合rt-PA及静脉注射肝素治疗股浅动脉闭塞似乎可预防再血栓形成。
