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终末期肝病模型评分25分及以上患者术中经食管超声心动图相关的胃食管及出血并发症。

Gastroesophageal and hemorrhagic complications associated with intraoperative transesophageal echocardiography in patients with model for end-stage liver disease score 25 or higher.

作者信息

Myo Bui Christine C, Worapot Apinyachon, Xia Wei, Delgado Lauren, Steadman Randolph H, Busuttil Ronald W, Xia Victor W

机构信息

David Geffen School of Medicine.

Department of Anesthesiology, Ramathibodi Hospital, Mahidol University, Bangkok Thailand.

出版信息

J Cardiothorac Vasc Anesth. 2015;29(3):594-7. doi: 10.1053/j.jvca.2014.10.030. Epub 2014 Nov 4.

Abstract

OBJECTIVE

To investigate major gastroesophageal and hemorrhagic complications that may be related to intraoperative transesophageal echocardiography (TEE) in liver transplant (LT) patients with high model for end-stage liver disease (MELD) score 25 or higher.

DESIGN

Retrospective.

SETTING

Single institution university setting.

PARTICIPANTS

Of 906 transplant recipients, 656 who had MELD score 25 or higher were included for analysis.

INTERVENTIONS

Patient demographics, pre- and intraoperative characteristics, and major gastroesophageal and hemorrhagic complications were compared between patients with and without TEE.

MEASUREMENTS AND MAIN RESULTS

Sixty-six percent (433 patients) had intraoperative TEE and 34% (223 patients) did not. One patient in the TEE group had a major gastroesophageal complication (Mallory-Weiss tear). Eleven patients required postoperative gastrointestinal consultation. These patients were distributed evenly between the TEE and non-TEE groups. Eighteen (2.8%) had major hemorrhagic complication (defined as bloody nasogastric output>500 mL in 24 hours postoperatively). Multivariate analysis showed alcoholic cirrhosis had 5.3 higher odds of post-transplant gastroesophageal hemorrhage compared with other indications for transplant (95% confidence interval 1.8-15.8, p<0.001). TEE was not associated with an increased likelihood of major hemorrhagic complication after LT.

CONCLUSIONS

The authors demonstrated that the incidence of major gastroesophageal and hemorrhagic complications following intraoperative TEE in LT patients with MELD score 25 or higher was low.

摘要

目的

调查终末期肝病模型(MELD)评分25分及以上的肝移植(LT)患者中,可能与术中经食管超声心动图(TEE)相关的主要胃食管和出血并发症。

设计

回顾性研究。

地点

单一机构的大学环境。

参与者

在906名移植受者中,纳入656名MELD评分25分及以上者进行分析。

干预措施

比较有TEE和无TEE患者的人口统计学、术前和术中特征,以及主要胃食管和出血并发症。

测量指标和主要结果

66%(433例患者)术中使用TEE,34%(223例患者)未使用。TEE组有1例患者发生主要胃食管并发症(马洛里-魏斯撕裂)。11例患者术后需要胃肠会诊。这些患者在TEE组和非TEE组中分布均匀。18例(2.8%)发生主要出血并发症(定义为术后24小时胃管血性引流量>500 mL)。多因素分析显示,与其他移植指征相比,酒精性肝硬化患者移植后胃食管出血的几率高5.3倍(95%置信区间1.8 - 15.8,p<0.001)。TEE与LT术后主要出血并发症的发生率增加无关。

结论

作者表明,MELD评分25分及以上的LT患者术中使用TEE后,主要胃食管和出血并发症的发生率较低。

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