微流控法制备形状可调的海藻酸钠微凝胶：尺寸和冲击速度的影响。

Microfluidic fabrication of shape-tunable alginate microgels: effect of size and impact velocity.

机构信息

Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, United States.

Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, United States; School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907, United States.

出版信息

Carbohydr Polym. 2015 Apr 20;120:38-45. doi: 10.1016/j.carbpol.2014.11.053. Epub 2014 Dec 9.

DOI:10.1016/j.carbpol.2014.11.053

PMID:25662685

Abstract

We report on a capillary-based microfluidic platform for the fabrication of non-spherical sodium alginate microgels. The sodium alginate droplets were crosslinked off-chip in a mixture of barium acetate and glycerol solution. Novel morphologies such as tear drop, lamp-like, mushroom-like, double-dimpled and bowl-like microgels were fabricated by controlling the size, impact velocity (at the crosslinking solution/oil interface), and concentration of sodium alginate solution. We monitored the microscale deformation process in situ at the interface and proposeed a deformation mechanism resulting in unique morphologies. Additionally, we constructed microgel superstructures by assembling the non-spherical alginate microgels to spherical poly(N-isopropylacrylamide) (pNIPAAm) microgels via electrostatic interaction.

摘要

我们报告了一种基于毛细管的微流控平台，用于制造非球形海藻酸钠微凝胶。海藻酸钠液滴在醋酸钡和甘油溶液的混合物中进行离片交联。通过控制液滴的大小、撞击速度（在交联溶液/油界面处）和海藻酸钠溶液的浓度，可以制备出泪滴状、灯状、蘑菇状、双凹陷状和碗状等新颖的微凝胶形态。我们在界面处原位监测微尺度变形过程，并提出了导致独特形态的变形机制。此外，我们通过静电相互作用将非球形海藻酸钠微凝胶组装到球形聚（N-异丙基丙烯酰胺）（pNIPAAm）微凝胶上，构建了微凝胶超结构。